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Antibody neutralization to SARS-CoV-2 and variants after one year in Wuhan, China.
Liu, Qianyun; Xiong, Qing; Mei, Fanghua; Ma, Chengbao; Zhang, Zhen; Hu, Bing; Xu, Junqiang; Jiang, Yongzhong; Zhan, Faxian; Zhou, Suhua; Tao, Li; Chen, Xianying; Guo, Ming; Wang, Xin; Fang, Yaohui; Shen, Shu; Liu, Yingle; Liu, Fang; Zhou, Li; Xu, Ke; Ke, Changwen; Deng, Fei; Cai, Kun; Yan, Huan; Chen, Yu; Lan, Ke.
  • Liu Q; State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Xiong Q; State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Mei F; Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China.
  • Ma C; State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Zhang Z; State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Hu B; Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China.
  • Xu J; Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China.
  • Jiang Y; Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China.
  • Zhan F; Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China.
  • Zhou S; Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China.
  • Tao L; Wuhan Jiang'an District Center for Disease Control and Prevention, Wuhan 430000, China.
  • Chen X; State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Guo M; State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Wang X; State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Fang Y; National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences,Wuhan 430071, China.
  • Shen S; National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences,Wuhan 430071, China.
  • Liu Y; State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Liu F; State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Zhou L; State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Xu K; State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Ke C; Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
  • Deng F; National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences,Wuhan 430071, China.
  • Cai K; Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China.
  • Yan H; State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Chen Y; State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Lan K; State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Innovation (N Y) ; : 100181, 2021 Nov 03.
Article in English | MEDLINE | ID: covidwho-1595417
ABSTRACT
Most COVID-19 convalescents can build effective anti-SARS-CoV-2 humoral immunity, but it remains unclear how long it can maintain and how efficiently it can prevent the reinfection of the emerging SARS-CoV-2 variants. Here, we tested the sera from 248 COVID-19 convalescents around one year post-infection in Wuhan, the earliest known epicenter. SARS-CoV-2 immunoglobulins G (IgG) were well maintained in most patients and potently neutralizes the infection of the original strain and the B.1.1.7 variant. However, varying degrees of immune escape was observed on the other tested variants in a patient-specific manner, with individuals showing remarkably broad neutralization potency. The immune escape can be largely attributed to several critical spike mutations. These results suggest that SARS-CoV-2 can elicit long-lasting immunity but escaped by the emerging variants.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Language: English Journal: Innovation (N Y) Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Language: English Journal: Innovation (N Y) Year: 2021
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