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Emergence of B.1.1.318 SARS-CoV-2 viral lineage and high incidence of alpha B.1.1.7 variant of concern in the Republic of Gabon.
Manouana, Gédéon Prince; Nzamba Maloum, Moustapha; Bikangui, Rodrigue; Oye Bingono, Sam O'neilla; Ondo Nguema, Georgelin; Honkpehedji, Josiane Yabo; Rossatanga, Elie Gide; Zoa-Assoumou, Samira; Pallerla, Srinivas Reddy; Rachakonda, Sivaramakrishna; Ndong Mintsa, Armel; Lekana-Douki, Jean-Bernard; Djoba Siawaya, Joël-Fleury; Borrmann, Steffen; Kremsner, Peter Gottfried; Lell, Bertrand; Velavan, Thirumalaisamy P; Adegnika, Ayola Akim.
  • Manouana GP; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Institute of Tropical Medicine, Universitätsklinikum Tübingen, Tübingen, Germany.
  • Nzamba Maloum M; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.
  • Bikangui R; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; École doctorale de Franceville, Franceville, Gabon.
  • Oye Bingono SO; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.
  • Ondo Nguema G; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.
  • Honkpehedji JY; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.
  • Rossatanga EG; Centre Hospitalier Régional Georges Rawiri de Lambaréné, Lambaréné, Gabon.
  • Zoa-Assoumou S; Laboratoire Professeur Daniel Gahouma, Libreville, Gabon; Département de Bactériologie-Virologie, Université des Sciences de la Santé, Libreville, Gabon.
  • Pallerla SR; Institute of Tropical Medicine, Universitätsklinikum Tübingen, Tübingen, Germany.
  • Rachakonda S; Institute of Tropical Medicine, Universitätsklinikum Tübingen, Tübingen, Germany.
  • Ndong Mintsa A; Laboratoire Professeur Daniel Gahouma, Libreville, Gabon.
  • Lekana-Douki JB; Centre Interdisciplinaire de Recherches Médicales de Franceville, France, Gabon.
  • Djoba Siawaya JF; Centre Hospitalier Universitaire Mère-enfant Fondation Jeanne EBORI, Libreville, Gabon.
  • Borrmann S; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Institute of Tropical Medicine, Universitätsklinikum Tübingen, Tübingen, Germany; German Center for Infection Research (DZIF), Tübingen, Germany.
  • Kremsner PG; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Institute of Tropical Medicine, Universitätsklinikum Tübingen, Tübingen, Germany; German Center for Infection Research (DZIF), Tübingen, Germany.
  • Lell B; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Institute of Tropical Medicine, Universitätsklinikum Tübingen, Tübingen, Germany; Medical University of Vienna, Vienna, Austria.
  • Velavan TP; Institute of Tropical Medicine, Universitätsklinikum Tübingen, Tübingen, Germany; Vietnamese-German Center for Medical Research, VG-CARE, Hanoi, Vietnam.
  • Adegnika AA; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Institute of Tropical Medicine, Universitätsklinikum Tübingen, Tübingen, Germany; German Center for Infection Research (DZIF), Tübingen, Germany; Fondation pour la Recherche Scientifique, Cotonou, Bénin. Electronic address: aadegnika@cer
Int J Infect Dis ; 114: 151-154, 2022 Jan.
Article in English | MEDLINE | ID: covidwho-1506382
ABSTRACT

OBJECTIVE:

Variants of concern (VOCs) associated with relatively high transmissibility appear to be rapidly spreading in Gabon. Therefore, it is imperative to understand the distribution of several VOCs in the population, which could have implications for transmissibility and vaccine efficacy.

METHODS:

Between February and May 2021, SARS-CoV-2 genomes were sequenced using the Oxford nanopore MinION method and the respective genome diversity was elucidated. Phylogenetic analysis was performed and genomes were classified using pangolin lineages.

RESULTS:

The results highlighted an increase (46%) in the alpha VOC (B.1.1.7) in the Gabonese population over the study period. In addition, an increase (31%) in the B.1.1.318 lineage, which is associated with high transmission and impaired vaccine efficacy (D614G+E484K+Y144del), was detected.

CONCLUSION:

With the second wave ongoing, these findings highlight the need for surveillance of the SARS-CoV-2 genome in the Republic of Gabon and should provide useful guidance to policymakers in selecting an appropriate vaccine for this population.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Country/Region as subject: Africa Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: J.ijid.2021.10.057

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Country/Region as subject: Africa Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: J.ijid.2021.10.057