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Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants.
McCallum, Matthew; Walls, Alexandra C; Sprouse, Kaitlin R; Bowen, John E; Rosen, Laura E; Dang, Ha V; De Marco, Anna; Franko, Nicholas; Tilles, Sasha W; Logue, Jennifer; Miranda, Marcos C; Ahlrichs, Margaret; Carter, Lauren; Snell, Gyorgy; Pizzuto, Matteo Samuele; Chu, Helen Y; Van Voorhis, Wesley C; Corti, Davide; Veesler, David.
  • McCallum M; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Walls AC; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Sprouse KR; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Bowen JE; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Rosen LE; Vir Biotechnology, San Francisco, CA 94158, USA.
  • Dang HV; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • De Marco A; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
  • Franko N; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98195, USA.
  • Tilles SW; Center for Emerging and Re-emerging Infectious Diseases, Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.
  • Logue J; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98195, USA.
  • Miranda MC; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Ahlrichs M; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Carter L; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Snell G; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Pizzuto MS; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Chu HY; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Van Voorhis WC; Vir Biotechnology, San Francisco, CA 94158, USA.
  • Corti D; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
  • Veesler D; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98195, USA.
Science ; 374(6575): 1621-1626, 2021 Dec 24.
Article in English | MEDLINE | ID: covidwho-1506414
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission leads to the emergence of variants, including the B.1.617.2 (Delta) variant of concern that is causing a new wave of infections and has become globally dominant. We show that these variants dampen the in vitro potency of vaccine-elicited serum neutralizing antibodies and provide a structural framework for describing their immune evasion. Mutations in the B.1.617.1 (Kappa) and Delta spike glycoproteins abrogate recognition by several monoclonal antibodies via alteration of key antigenic sites, including remodeling of the Delta amino-terminal domain. The angiotensin-converting enzyme 2 binding affinities of the Kappa and Delta receptor binding domains are comparable to the Wuhan-Hu-1 isolate, whereas B.1.617.2+ (Delta+) exhibits markedly reduced affinity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immune Evasion / Spike Glycoprotein, Coronavirus / COVID-19 Vaccines / SARS-CoV-2 Topics: Vaccines / Variants Limits: Humans Language: English Journal: Science Year: 2021 Document Type: Article Affiliation country: Science.abl8506

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immune Evasion / Spike Glycoprotein, Coronavirus / COVID-19 Vaccines / SARS-CoV-2 Topics: Vaccines / Variants Limits: Humans Language: English Journal: Science Year: 2021 Document Type: Article Affiliation country: Science.abl8506