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Role of multiple factors likely contributing to severity-mortality of COVID-19.
Singh, Jasdeep; Alam, Anwar; Samal, Jasmine; Maeurer, Markus; Ehtesham, Nasreen Z; Chakaya, Jeremiah; Hira, Subhash; Hasnain, Seyed E.
  • Singh J; Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology-Delhi, New Delhi, India.
  • Alam A; ICMR National Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India.
  • Samal J; ICMR National Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India.
  • Maeurer M; ImmunoSurgery Unit, Champalimaud Centre for the Unknown, Lisbon, Portugal; Medizinische Klinik, Johannes Gutenberg University Mainz, Germany; Division of Infection and Immunity, University College London, London, UK; NIHR Biomedical Research Centre, University College London Hospitals, London, UK.
  • Ehtesham NZ; ICMR National Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India.
  • Chakaya J; Division of Infection and Immunity, University College London, London, UK; NIHR Biomedical Research Centre, University College London Hospitals, London, UK; Department of Medicine, Therapeutics, Dermatology and Psychiatry, Kenyatta University, Nairobi, Kenya. Electronic address: chakaya.jm@gmail.com
  • Hira S; Department of Global Health, University of Washington-Seattle, USA. Electronic address: Hiras2@uw.edu.
  • Hasnain SE; Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology-Delhi, New Delhi, India; Department of Life Science, School of Basic Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India. Electronic address: seyed.hasnain@sharda.ac.in.
Infect Genet Evol ; 96: 105101, 2021 12.
Article in English | MEDLINE | ID: covidwho-1506832
ABSTRACT
COVID-19 stalled the world in 2020 and continues to be the greatest health crisis of this generation. While the apparent case fatality rates across fluctuates around ~2% globally, associated mortality/death rate (deaths per million population) varies distinctly across regions from the global average of ~600 per million population. Heterogeneous factors have been linked with COVID-19 associated mortalities and these include age, share of geriatric population, comorbidities, trained immunity and climatic conditions. Apart from direct or indirect role of endemic diseases, dietary factors and host immunity in regulating COVID-19 severity, human behaviour will inevitably control outcome of this pandemic. Comprehensive understanding of these factors will have a bearing on management of future health crises.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study / Qualitative research Topics: Vaccines Limits: Humans Language: English Journal: Infect Genet Evol Journal subject: Biology / Communicable Diseases / Genetics Year: 2021 Document Type: Article Affiliation country: J.meegid.2021.105101

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study / Qualitative research Topics: Vaccines Limits: Humans Language: English Journal: Infect Genet Evol Journal subject: Biology / Communicable Diseases / Genetics Year: 2021 Document Type: Article Affiliation country: J.meegid.2021.105101