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D-dimer, disease severity, and deaths (3D-study) in patients with COVID-19: a systematic review and meta-analysis of 100 studies.
Varikasuvu, Seshadri Reddy; Varshney, Saurabh; Dutt, Naveen; Munikumar, Manne; Asfahan, Shahir; Kulkarni, Paresh P; Gupta, Pratima.
  • Varikasuvu SR; Department of Biochemistry, All India Institute of Medical Sciences, Deoghar, 814142, India. lifeschemistry@live.com.
  • Varshney S; All India Institute of Medical Sciences, Deoghar, 814142, India.
  • Dutt N; Department of Respiratory Medicine, All India Institute of Medical Sciences, Jodhpur, 342005, India.
  • Munikumar M; Department of Bioinformatics, ICMR-National Institute of Nutrition, Hyderabad, 500007, India.
  • Asfahan S; Department of Respiratory Medicine, All India Institute of Medical Sciences, Jodhpur, 342005, India.
  • Kulkarni PP; Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
  • Gupta P; Department of Microbiology, All India Institute of Medical Sciences, Rishikesh, 249203, India.
Sci Rep ; 11(1): 21888, 2021 11 08.
Article in English | MEDLINE | ID: covidwho-1506965
ABSTRACT
Hypercoagulability and the need for prioritizing coagulation markers for prognostic abilities have been highlighted in COVID-19. We aimed to quantify the associations of D-dimer with disease progression in patients with COVID-19. This systematic review and meta-analysis was registered with PROSPERO, CRD42020186661.We included 113 studies in our systematic review, of which 100 records (n = 38,310) with D-dimer data) were considered for meta-analysis. Across 68 unadjusted (n = 26,960) and 39 adjusted studies (n = 15,653) reporting initial D-dimer, a significant association was found in patients with higher D-dimer for the risk of overall disease progression (unadjusted odds ratio (uOR) 3.15; adjusted odds ratio (aOR) 1.64). The time-to-event outcomes were pooled across 19 unadjusted (n = 9743) and 21 adjusted studies (n = 13,287); a strong association was found in patients with higher D-dimers for the risk of overall disease progression (unadjusted hazard ratio (uHR) 1.41; adjusted hazard ratio (aHR) 1.10). The prognostic use of higher D-dimer was found to be promising for predicting overall disease progression (studies 68, area under curve 0.75) in COVID-19. Our study showed that higher D-dimer levels provide prognostic information useful for clinicians to early assess COVID-19 patients at risk for disease progression and mortality outcomes. This study, recommends rapid assessment of D-dimer for predicting adverse outcomes in COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Fibrin Fibrinogen Degradation Products / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-01462-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Fibrin Fibrinogen Degradation Products / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-01462-5