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Temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus infection.
Yewdell, William T; Smolkin, Ryan M; Belcheva, Kalina T; Mendoza, Alejandra; Michaels, Anthony J; Cols, Montserrat; Angeletti, Davide; Yewdell, Jonathan W; Chaudhuri, Jayanta.
  • Yewdell WT; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: yewdellw@mskcc.org.
  • Smolkin RM; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY 10065, USA.
  • Belcheva KT; Biochemistry, Cellular, and Molecular Biology Allied Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
  • Mendoza A; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Michaels AJ; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
  • Cols M; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Angeletti D; Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, 41390 Gothenburg, Sweden.
  • Yewdell JW; Laboratory of Viral Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Chaudhuri J; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA. El
Cell Rep ; 37(6): 109961, 2021 11 09.
Article in English | MEDLINE | ID: covidwho-1507742
ABSTRACT
Following infection or immunization, memory B cells (MBCs) and long-lived plasma cells provide humoral immunity that can last for decades. Most principles of MBC biology have been determined with hapten-protein carrier models or fluorescent protein immunizations. Here, we examine the temporal dynamics of the germinal center (GC) B cell and MBC response following mouse influenza A virus infection. We find that antiviral B cell responses within the lung-draining mediastinal lymph node (mLN) and the spleen are distinct in regard to duration, enrichment for antigen-binding cells, and class switching dynamics. While splenic GCs dissolve after 6 weeks post-infection, mLN hemagglutinin-specific (HA+) GCs can persist for 22 weeks. Persistent GCs continuously differentiate MBCs, with "peak" and "late" GCs contributing equal numbers of HA+ MBCs to the long-lived compartment. Our findings highlight critical aspects of persistent GC responses and MBC differentiation following respiratory virus infection with direct implications for developing effective vaccination strategies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza A virus / Orthomyxoviridae Infections / Germinal Center / T-Box Domain Proteins / Memory B Cells / Immunologic Memory / Antibodies, Viral Topics: Vaccines Limits: Animals Language: English Journal: Cell Rep Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza A virus / Orthomyxoviridae Infections / Germinal Center / T-Box Domain Proteins / Memory B Cells / Immunologic Memory / Antibodies, Viral Topics: Vaccines Limits: Animals Language: English Journal: Cell Rep Year: 2021 Document Type: Article