Temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus infection.
Cell Rep
; 37(6): 109961, 2021 11 09.
Article
in English
| MEDLINE | ID: covidwho-1507742
ABSTRACT
Following infection or immunization, memory B cells (MBCs) and long-lived plasma cells provide humoral immunity that can last for decades. Most principles of MBC biology have been determined with hapten-protein carrier models or fluorescent protein immunizations. Here, we examine the temporal dynamics of the germinal center (GC) B cell and MBC response following mouse influenza A virus infection. We find that antiviral B cell responses within the lung-draining mediastinal lymph node (mLN) and the spleen are distinct in regard to duration, enrichment for antigen-binding cells, and class switching dynamics. While splenic GCs dissolve after 6 weeks post-infection, mLN hemagglutinin-specific (HA+) GCs can persist for 22 weeks. Persistent GCs continuously differentiate MBCs, with "peak" and "late" GCs contributing equal numbers of HA+ MBCs to the long-lived compartment. Our findings highlight critical aspects of persistent GC responses and MBC differentiation following respiratory virus infection with direct implications for developing effective vaccination strategies.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Influenza A virus
/
Orthomyxoviridae Infections
/
Germinal Center
/
T-Box Domain Proteins
/
Memory B Cells
/
Immunologic Memory
/
Antibodies, Viral
Topics:
Vaccines
Limits:
Animals
Language:
English
Journal:
Cell Rep
Year:
2021
Document Type:
Article
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