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Races of small molecule clinical trials for the treatment of COVID-19: An up-to-date comprehensive review.
Hu, Suwen; Jiang, Songwei; Qi, Xiang; Bai, Renren; Ye, Xiang-Yang; Xie, Tian.
  • Hu S; School of Pharmacy, Hangzhou Normal University, Hangzhou, China.
  • Jiang S; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, Hangzhou Normal University, Hangzhou, China.
  • Qi X; Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou Normal University, Hangzhou, China.
  • Bai R; Collaborative Innovation Center of Chinese Medicines from Zhejiang Province, Hangzhou Normal Umiversity, Hangzhou, China.
  • Ye XY; Hangzhou Huadong Medicine Group, Pharmaceutical Research Institute Co. Ltd., Hangzhou, China.
  • Xie T; Department of Chemistry and Biochemistry Los Angeles, University of California, Los Angeles, California, USA.
Drug Dev Res ; 83(1): 16-54, 2022 02.
Article in English | MEDLINE | ID: covidwho-1508642
ABSTRACT
The coronavirus disease-19 (COVID-19) pandemic has become a global threat since its first outbreak at the end of 2019. Several review articles have been published recently, focusing on the aspects of target biology, drug repurposing, and mechanisms of action (MOAs) for potential treatment. This review gathers all small molecules currently in active clinical trials, categorizes them into six sub-classes, and summarizes their clinical progress. The aim is to provide the researchers from both pharmaceutical industries and academic institutes with the handful information and dataset to accelerate their research programs in searching effective small molecule therapy for treatment of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Clinical Trials as Topic / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Drug Dev Res Year: 2022 Document Type: Article Affiliation country: Ddr.21895

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Clinical Trials as Topic / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Drug Dev Res Year: 2022 Document Type: Article Affiliation country: Ddr.21895