Inflammation, Oxidative Stress, and Bone in Chronic Kidney Disease in the Osteoimmunology Era.
Calcif Tissue Int
; 108(4): 452-460, 2021 04.
Article
in English
| MEDLINE | ID: covidwho-1509222
ABSTRACT
Bone is not only a mineralized and apparently non-vital structure that provides support for locomotion and protection to inner organs. An increasing number of studies are unveiling new biologic functions and connections to other systems, giving the rise to new fields of research, such as osteoimmunology. The bone marrow niche, a new entity in bone physiology, seems to represent the site where a complex crosstalk between bone and immune/inflammatory responses takes place. An impressive interplay with the immune system is realized in bone marrow, with reciprocal influences between bone cells and haematopoietic cells. In this way, systemic chronic inflammatory diseases realize a crosstalk with bone, resulting in bone disease. Thus, pathogenetic links between chronic kidney disease-mineral bone disorders and osteoporosis, cardiovascular disease, and ageing are common. The aim of this narrative review is to provide a general view of the progresses in the field of bone research and their potential clinical implications, with emphasis on the links with inflammation and the connections to osteoimmunology and chemokines.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Bone and Bones
/
Renal Insufficiency, Chronic
Type of study:
Prognostic study
/
Reviews
Limits:
Humans
Language:
English
Journal:
Calcif Tissue Int
Year:
2021
Document Type:
Article
Affiliation country:
S00223-020-00794-0
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