Lack of Prognostic Value of SARS-CoV2 RT-PCR Cycle Threshold in the Community.
Infect Dis Ther
; 11(1): 587-593, 2022 Feb.
Article
in English
| MEDLINE | ID: covidwho-1682191
ABSTRACT
The immense impact of the COVID-19 pandemic on health systems has motivated the scientific community to search for clinical prognostic factors for SARS-CoV-2 infection. Low cycle threshold values (Ct) of diagnostic real-time RT-PCR assays in hospitalized patients have been associated with a poor prognosis in several studies, whereas other studies did not find this association. We explored whether SARS-CoV-2 Ct values at diagnosis were associated with a poor outcome (admission to hospital and death) in 604 community patients diagnosed at primary health centers. Although lower Ct values were found in patients who died of COVID-19, the Ct value was not significantly associated with a worse outcome in a multivariate analysis, while age remained an independent prognostic factor. We did not find evidence to support the role of Ct values as a prognostic factor of COVID-19 in community cases.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Prognostic study
Language:
English
Journal:
Infect Dis Ther
Year:
2022
Document Type:
Article
Affiliation country:
S40121-021-00561-0
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