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Beyond TGFß1 - novel treatment strategies targeting lung fibrosis.
Sim, Claudia; Lamanna, Emma; Cirnigliaro, Frank; Lam, Maggie.
  • Sim C; Monash University, Clayton, Melbourne, Australia.
  • Lamanna E; Monash University, Clayton, Melbourne, Australia.
  • Cirnigliaro F; Monash University, Clayton, Melbourne, Australia.
  • Lam M; Monash University, Clayton, Melbourne, Australia. Electronic address: maggie.lam@monash.edu.
Int J Biochem Cell Biol ; 141: 106090, 2021 12.
Article in English | MEDLINE | ID: covidwho-1509589
ABSTRACT
Fibrosis is a key feature of chronic lung diseases and occurs as a consequence of aberrant wound healing. TGFß1 plays a major role in promoting fibrosis and is the primary target of current treatments that slow, but do not halt or reverse the progression of disease. Accumulating evidence suggests that additional mechanisms, including excessive airway contraction, inflammation and infections including COVID-19, can contribute to fibrosis. This review summarises experimental and clinical studies assessing the potential beneficial effects of novel drugs that possess a unique suite of complementary actions to oppose contraction, inflammation and remodelling, along with evidence that they also limit fibrosis. Translation of these promising findings is critical for the repurposing and development of improved therapeutics for fibrotic lung diseases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Transforming Growth Factor beta1 / Lung Type of study: Prognostic study Limits: Humans Language: English Journal: Int J Biochem Cell Biol Journal subject: Biochemistry Year: 2021 Document Type: Article Affiliation country: J.biocel.2021.106090

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Transforming Growth Factor beta1 / Lung Type of study: Prognostic study Limits: Humans Language: English Journal: Int J Biochem Cell Biol Journal subject: Biochemistry Year: 2021 Document Type: Article Affiliation country: J.biocel.2021.106090