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Anti-AT1R autoantibodies and prediction of the severity of Covid-19.
Papola, Franco; Biancofiore, Veronica; Angeletti, Chiara; Grimaldi, Alessandro; Carucci, Anna Cecilia; Cofini, Vincenza; Necozione, Stefano; Rosciano, Alessia; Marinangeli, Franco; Cervelli, Carla.
  • Papola F; Regional Centre of Immunohaematology and Tissue Typing, S.Salvatore Hospital, L'Aquila, Italy. Electronic address: fpapola@asl1abruzzo.it.
  • Biancofiore V; Anesthesiology, Intensive Care and Pain Medicine, Emergency Department, S.Salvatore Hospital L'Aquila, Italy.
  • Angeletti C; Anesthesiology, Intensive Care and Pain Medicine, Emergency Department Civil Hospital G. Mazzini of Teramo, Teramo, Italy.
  • Grimaldi A; Infective Disease Department S.Salvatore Hospital L'Aquila, Italy.
  • Carucci AC; Infective Disease Department S.Salvatore Hospital L'Aquila, Italy.
  • Cofini V; Department of Life, Health and Environmental Science, University of L'Aquila, 67100 L'Aquila, Italy.
  • Necozione S; Department of Life, Health and Environmental Science, University of L'Aquila, 67100 L'Aquila, Italy.
  • Rosciano A; Regional Centre of Immunohaematology and Tissue Typing, S.Salvatore Hospital, L'Aquila, Italy.
  • Marinangeli F; Anesthesiology, Intensive Care and Pain Medicine, Emergency Department Civil Hospital G. Mazzini of Teramo, Teramo, Italy.
  • Cervelli C; Regional Centre of Immunohaematology and Tissue Typing, S.Salvatore Hospital, L'Aquila, Italy.
Hum Immunol ; 83(2): 130-133, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1509823
ABSTRACT
The stimulation of AT1R (Angiotensin II Receptor Type 1) by Angiotensin II has, in addition to the effects on the renin-angiotensin system, also pro-inflammatory effects through stimulation of ADAM17 and subsequent production of INF-gamma and Interleukin-6. This pro-inflammatory action stimulate the cytokine storm that characterizes the most severe forms of SARS-CoV-2 infection. We studied the effect of AT1Rab on the AT1R on 74 subjects with SARS-CoV-2 infection with respiratory symptoms requiring hospitalization. We divided the patients into 2 groups 34 with moderate and 40 with severe symptoms that required ICU admission. Hospitalized subjects showed a 50% reduction in the frequency of AT1Rab compared to healthy reference population. Of the ICU patients, 33/40 (82.5%) were AT1Rab negative and 16/33 of them (48.5%) died. All 7 patients positive for AT1Rab survived. These preliminary data seem to indicate a protective role played by AT1R autoantibodies on inflammatory activation in SARS-CoV-2 infection pathology.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoantibodies / Receptor, Angiotensin, Type 1 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Hum Immunol Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoantibodies / Receptor, Angiotensin, Type 1 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Hum Immunol Year: 2022 Document Type: Article