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Emergence of B.1.524(G) SARS-CoV-2 in Malaysia during the third COVID-19 epidemic wave.
Tan, Kim-Kee; Tan, Jia-Yi; Wong, Jo-Ern; Teoh, Boon-Teong; Tiong, Vunjia; Abd-Jamil, Juraina; Nor'e, Siti-Sarah; Khor, Chee-Sieng; Johari, Jefree; Yaacob, Che-Norainon; Zulkifli, Mulya-Mustika-Sari; CheMatSeri, AsmaAnati; Mahfodz, Nur-Hidayana; Azizan, Noor Syahida; AbuBakar, Sazaly.
  • Tan KK; Tropical Infectious Diseases Research and Education Centre (TIDREC), Higher Institution Centre of Excellence (HICoE), Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
  • Tan JY; Tropical Infectious Diseases Research and Education Centre (TIDREC), Higher Institution Centre of Excellence (HICoE), Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
  • Wong JE; Tropical Infectious Diseases Research and Education Centre (TIDREC), Higher Institution Centre of Excellence (HICoE), Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
  • Teoh BT; Tropical Infectious Diseases Research and Education Centre (TIDREC), Higher Institution Centre of Excellence (HICoE), Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
  • Tiong V; Tropical Infectious Diseases Research and Education Centre (TIDREC), Higher Institution Centre of Excellence (HICoE), Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
  • Abd-Jamil J; Tropical Infectious Diseases Research and Education Centre (TIDREC), Higher Institution Centre of Excellence (HICoE), Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
  • Nor'e SS; Tropical Infectious Diseases Research and Education Centre (TIDREC), Higher Institution Centre of Excellence (HICoE), Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
  • Khor CS; Tropical Infectious Diseases Research and Education Centre (TIDREC), Higher Institution Centre of Excellence (HICoE), Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
  • Johari J; Tropical Infectious Diseases Research and Education Centre (TIDREC), Higher Institution Centre of Excellence (HICoE), Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
  • Yaacob CN; Tropical Infectious Diseases Research and Education Centre (TIDREC), Higher Institution Centre of Excellence (HICoE), Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
  • Zulkifli MM; Tropical Infectious Diseases Research and Education Centre (TIDREC), Higher Institution Centre of Excellence (HICoE), Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
  • CheMatSeri A; Tropical Infectious Diseases Research and Education Centre (TIDREC), Higher Institution Centre of Excellence (HICoE), Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
  • Mahfodz NH; Tropical Infectious Diseases Research and Education Centre (TIDREC), Higher Institution Centre of Excellence (HICoE), Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
  • Azizan NS; Tropical Infectious Diseases Research and Education Centre (TIDREC), Higher Institution Centre of Excellence (HICoE), Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
  • AbuBakar S; Tropical Infectious Diseases Research and Education Centre (TIDREC), Higher Institution Centre of Excellence (HICoE), Universiti Malaya, 50603, Kuala Lumpur, Malaysia. sazaly@um.edu.my.
Sci Rep ; 11(1): 22105, 2021 11 11.
Article in English | MEDLINE | ID: covidwho-1758317
ABSTRACT
The COVID-19 pandemic first emerged in Malaysia in Jan 2020. As of 12th Sept 2021, 1,979,698 COVID-19 cases that occurred over three major epidemic waves were confirmed. The virus contributing to the three epidemic waves has not been well-studied. We sequenced the genome of 22 SARS-CoV-2 strains detected in Malaysia during the second and the ongoing third wave of the COVID-19 epidemic. Detailed phylogenetic and genetic variation analyses of the SARS-CoV-2 isolate genomes were performed using these newly determined sequences and all other available sequences. Results from the analyses suggested multiple independent introductions of SARS-CoV-2 into Malaysia. A new B.1.524(G) lineage with S-D614G mutation was detected in Sabah, East Malaysia and Selangor, Peninsular Malaysia on 7th October 2020 and 14th October 2020, respectively. This new B.1.524(G) group was not the direct descendant of any of the previously detected lineages. The new B.1.524(G) carried a set of genetic variations, including A701V (position variant frequency = 0.0007) in Spike protein and a novel G114T mutation at the 5'UTR. The biological importance of the specific mutations remained unknown. The sequential appearance of the mutations, however, suggests that the spread of the new B.1.524(G) lineages likely begun in Sabah and then spread to Selangor. The findings presented here support the importance of SARS-CoV-2 full genome sequencing as a tool to establish an epidemiological link between cases or clusters of COVID-19 worldwide.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Randomized controlled trials Topics: Variants Limits: Humans Country/Region as subject: Asia Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-01223-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Randomized controlled trials Topics: Variants Limits: Humans Country/Region as subject: Asia Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-01223-4