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Oral Vaccination Protects Against Severe Acute Respiratory Syndrome Coronavirus 2 in a Syrian Hamster Challenge Model.
Johnson, Susan; Martinez, Clarissa I; Tedjakusuma, Sarah N; Peinovich, Nadine; Dora, Emery G; Birch, Sharla M; Kajon, Adriana E; Werts, Adam D; Tucker, Sean N.
  • Johnson S; Vaxart, South San Francisco, California, USA.
  • Martinez CI; Vaxart, South San Francisco, California, USA.
  • Tedjakusuma SN; Vaxart, South San Francisco, California, USA.
  • Peinovich N; Vaxart, South San Francisco, California, USA.
  • Dora EG; Vaxart, South San Francisco, California, USA.
  • Birch SM; Lovelace Biomedical Research Institute, Albuquerque, New Mexico, USA.
  • Kajon AE; Lovelace Biomedical Research Institute, Albuquerque, New Mexico, USA.
  • Werts AD; Lovelace Biomedical Research Institute, Albuquerque, New Mexico, USA.
  • Tucker SN; Vaxart, South San Francisco, California, USA.
J Infect Dis ; 225(1): 34-41, 2022 01 05.
Article in English | MEDLINE | ID: covidwho-1605626
ABSTRACT

BACKGROUND:

Vaccines that are shelf stable and easy to administer are crucial to improve vaccine access and reduce severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission around the world.

METHODS:

In this study, we demonstrate that an oral, adenovirus-based vaccine candidate protects against SARS-CoV-2 in a Syrian hamster challenge model.

RESULTS:

Hamsters administered 2 doses of VXA-CoV2-1 showed a reduction in weight loss and lung pathology and had completely eliminated infectious virus 5 days postchallenge. Oral immunization induced antispike immunoglobulin G, and neutralizing antibodies were induced upon oral immunization with the sera, demonstrating neutralizing activity.

CONCLUSIONS:

Overall, these data demonstrate the ability of oral vaccine candidate VXA-CoV2-1 to provide protection against SARS-CoV-2 disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Mesocricetus / Adenovirus Vaccines / COVID-19 Vaccines / COVID-19 Topics: Vaccines Limits: Animals Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Mesocricetus / Adenovirus Vaccines / COVID-19 Vaccines / COVID-19 Topics: Vaccines Limits: Animals Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis