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Accuracy of anterior nasal swab rapid antigen tests compared with RT-PCR for massive SARS-CoV-2 screening in low prevalence population.
Jakobsen, Kathrine Kronberg; Jensen, Jakob Schmidt; Todsen, Tobias; Kirkby, Nikolai; Lippert, Freddy; Vangsted, Anne-Marie; Klokker, Mads; von Buchwald, Christian.
  • Jakobsen KK; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Jensen JS; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Todsen T; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Kirkby N; Copenhagen Academy for Medical Education and Simulation, Copenhagen, Denmark.
  • Lippert F; Department of Clinical Microbiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Vangsted AM; Copenhagen Emergency Medical Services, University of Copenhagen, Copenhagen, Denmark.
  • Klokker M; Testcenter Danmark, Statens Serum Institut, Copenhagen, Denmark.
  • von Buchwald C; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
APMIS ; 130(2): 95-100, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1511282
ABSTRACT
The aim was to determine the accuracy of anterior nasal swab in rapid antigen (Ag) tests in a low SARS-CoV-2 prevalence and massive screened community. Individuals, aged 18 years or older, who self-booked an appointment for real-time reverse transcriptase-polymerase chain reaction (RT-PCR) test in March 2021 at a public test center in Copenhagen, Denmark were included. An oropharyngeal swab was collected for RT-PCR testing, followed by a swab from the anterior parts of the nose examined by Ag test (SD Biosensor). Accuracy of the Ag test was calculated with RT-PCR as reference. We included 7074 paired conclusive tests (n = 3461, female 50.7%). The median age was 48 years (IQR 36-57 years). The prevalence was 0.9%, that is, 66 tests were positive on RT-PCR. Thirty-two had a paired positive Ag test. The sensitivity was 48.5% and the specificity was 100%. This study conducted in a low prevalence setting in a massive screening set-up showed that the Ag test had a sensitivity of 48.5% and a specificity of 100%, that is, no false positive tests. The lower sensitivity is a challenge especially if Ag testing is not repeated frequently allowing this scalable test to be a robust supplement to RT-PCR testing in an ambitious public SARS-CoV-2 screening.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Nose / Reverse Transcriptase Polymerase Chain Reaction / COVID-19 Serological Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: APMIS Journal subject: Allergy and Immunology / Microbiology / Pathology Year: 2022 Document Type: Article Affiliation country: Apm.13189

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Nose / Reverse Transcriptase Polymerase Chain Reaction / COVID-19 Serological Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: APMIS Journal subject: Allergy and Immunology / Microbiology / Pathology Year: 2022 Document Type: Article Affiliation country: Apm.13189