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Protocol for a prospective multisite cohort study investigating hysterectomy versus uterine preservation for pelvic organ prolapse surgery: the HUPPS study.
Scime, Natalie V; Ramage, Kaylee; Brennand, Erin A.
  • Scime NV; Department of Community Health Sciences, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada.
  • Ramage K; Department of Community Health Sciences, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada.
  • Brennand EA; Department of Community Health Sciences, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada erin.brennand@albertahealthservices.ca.
BMJ Open ; 11(10): e053679, 2021 10 04.
Article in English | MEDLINE | ID: covidwho-1511477
ABSTRACT

INTRODUCTION:

Pelvic organ prolapse (POP) is the descent of pelvic organs into the vagina resulting in bulge symptoms and occurs in approximately 50% of women. Almost 20% of women will elect surgical correction of this condition by age 85. Removal of the uterus (hysterectomy) with concomitant vaginal vault suspension is a long-standing practice in POP surgery to address apical (uterine) prolapse. Yet, contemporary evidence on the merits of this approach relative to preservation of the uterus through suspension is needed to better inform surgical decision making by patients and their healthcare providers. The objective of this study is to evaluate POP-specific health outcomes and service utilisation of women electing uterine suspension compared with those electing hysterectomy and vaginal vault suspension for POP surgery up to 1-year postsurgery. METHODS AND

ANALYSIS:

This is a prospective cohort study planning to enrol 321 adult women with stage ≥2 POP from multiple sites in Alberta, Canada. Following standardised counselling from study surgeons, participants self-select either a hysterectomy based or uterine preservation surgical group. Data are being collected through participant questionnaires, medical records and administrative data linkage at four time points spanning from the presurgical consultation to 1-year postsurgery. The primary outcome is anatomic failure to correct POP, and secondary outcomes include changes in positioning of pelvic structures, retreatment, subjective report of bulge symptoms, pelvic floor distress and impact, sexual function and health service use. Data will be analysed using inverse probability weighting of propensity scores and generalised linear models. ETHICS AND DISSEMINATION This study is approved by the Conjoint Health Research Ethics Board at the University of Calgary (REB19-2134). Results will be disseminated via peer-reviewed publications, presentations at national and international conferences, and educational handouts for patients. TRIAL REGISTRATION NUMBER NCT04890951.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Uterine Prolapse / Pelvic Organ Prolapse Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans Country/Region as subject: North America Language: English Journal: BMJ Open Year: 2021 Document Type: Article Affiliation country: Bmjopen-2021-053679

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Uterine Prolapse / Pelvic Organ Prolapse Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans Country/Region as subject: North America Language: English Journal: BMJ Open Year: 2021 Document Type: Article Affiliation country: Bmjopen-2021-053679