A Review of Platelet-Activating Factor As a Potential Contributor to Morbidity and Mortality Associated with Severe COVID-19.

Klein, Mark; Dao, Vinh; Khan, Fatima

Klein, Mark; Dao, Vinh; Khan, Fatima.

Klein M; 20040Minneapolis Veterans Affairs Healthcare System, Minneapolis, MN, 55417, USA.
Dao V; University of Minnesota, MN, USA.
Khan F; 20040Minneapolis Veterans Affairs Healthcare System, Minneapolis, MN, 55417, USA.

Clin Appl Thromb Hemost ; 27: 10760296211051764, 2021.

Article in English | MEDLINE | ID: covidwho-1511654

ABSTRACT

ABSTRACT

The precise mechanisms of pathology in severe COVID-19 remains elusive. Current evidence suggests that inflammatory mediators are responsible for the manifestation of clinical symptoms that precedes a fatal response to infection. This review examines the nature of platelet activating factor and emphasizes the similarities between the physiological effects of platelet activating factor and the clinical complications of severe COVID-19.

Subject(s)

COVID-19/metabolism; Platelet Activating Factor/metabolism; Animals; COVID-19/complications; COVID-19/mortality; COVID-19/pathology; Humans; Inflammation/complications; Inflammation/metabolism; Inflammation/mortality; Inflammation/pathology; Multiple Organ Failure/complications; Multiple Organ Failure/metabolism; Multiple Organ Failure/mortality; Multiple Organ Failure/pathology; Respiratory Distress Syndrome/complications; Respiratory Distress Syndrome/metabolism; Respiratory Distress Syndrome/mortality; Respiratory Distress Syndrome/pathology; SARS-CoV-2/physiology; Severity of Illness Index; Thrombosis/complications; Thrombosis/metabolism; Thrombosis/mortality; Thrombosis/pathology

Keywords

COVID-19; platelet activating factor; thrombosis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Platelet Activating Factor / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Journal: Clin Appl Thromb Hemost Journal subject: Vascular Diseases Year: 2021 Document Type: Article Affiliation country: 10760296211051764

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