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SARS-CoV-2-related Progressive Brain White Matter Lesion Associated with an Increased Cerebrospinal Fluid Level of IL-6.
Oka, Yuwa; Ueda, Akihiro; Nakagawa, Tomokazu; Kikuchi, Yujiro; Inoue, Daiki; Marumo, Satoshi; Matsumoto, Sadayuki.
  • Oka Y; Department of Neurology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Japan.
  • Ueda A; Department of Neurology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Japan.
  • Nakagawa T; Department of Neurology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Japan.
  • Kikuchi Y; Respiratory Disease Center, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Japan.
  • Inoue D; Respiratory Disease Center, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Japan.
  • Marumo S; Respiratory Disease Center, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Japan.
  • Matsumoto S; Department of Neurology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Japan.
Intern Med ; 60(19): 3167-3170, 2021 Oct 01.
Article in English | MEDLINE | ID: covidwho-1511912
ABSTRACT
We herein report a 49-year-old man with a fever, diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. After two weeks of hospitalization, he suddenly mentioned visual field impairment. Computed tomography and magnetic resonance imaging revealed white matter damage and vasogenic edema. Cerebrospinal fluid showed increased levels of interleukin (IL)-6. His symptoms and white matter lesion deteriorated. After treatment with intravenous methylprednisolone therapy and plasmapheresis, his symptoms and white matter lesion improved gradually. We suspect that our patient was affected by a secondary hyperinflammatory syndrome related to cytokines, alone or in combination with direct viral injury through endothelial cell damage. The IL-6 levels were elevated only in the cerebrospinal fluid, suggesting focal central nervous system inflammation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interleukin-6 / White Matter / COVID-19 Type of study: Case report Topics: Long Covid Limits: Humans / Male / Middle aged Language: English Journal: Intern Med Journal subject: Internal Medicine Year: 2021 Document Type: Article Affiliation country: Internalmedicine.8123-21

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interleukin-6 / White Matter / COVID-19 Type of study: Case report Topics: Long Covid Limits: Humans / Male / Middle aged Language: English Journal: Intern Med Journal subject: Internal Medicine Year: 2021 Document Type: Article Affiliation country: Internalmedicine.8123-21