Pure red cell aplasia accompanied by COVID-19 successfully treated using cyclosporine.
J Infect Chemother
; 28(2): 304-307, 2022 Feb.
Article
in English
| MEDLINE | ID: covidwho-1514214
ABSTRACT
A 67-year-old Japanese man was admitted to our hospital with severe coronavirus disease 2019 (COVID-19) in March 2020. Mechanical ventilation was initiated 8 days after admission, due to severe respiratory failure. Multiple severe complications such as liver dysfunction, arrhythmia, brain infarction, and venous thromboembolism were also observed. We initially diagnosed Coombs test-positive warm autoimmune hemolytic anemia. Corticosteroids proved ineffective and anemia worsened with severe erythroid hypoplasia (0.5% erythroblasts in bone marrow), so we diagnosed pure red cell aplasia (PRCA). We also identified massive infiltration of cytotoxic T-lymphocytes expressing CD8, granzyme B, and perforin in bone marrow. Systemic cyclosporine was started, with full resolution of anemia and no need for blood transfusions after 4 weeks. We believe that this represents the first report of COVID-19-associated PRCA successfully treated using cyclosporine.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Red-Cell Aplasia, Pure
/
COVID-19
/
Anemia, Hemolytic, Autoimmune
Type of study:
Case report
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
J Infect Chemother
Journal subject:
Microbiology
/
Drug Therapy
Year:
2022
Document Type:
Article
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