Nitrofurantoin-induced agranulocytosis.
BMJ Case Rep
; 14(11)2021 Nov 11.
Article
in English
| MEDLINE | ID: covidwho-1515267
ABSTRACT
Idiosyncratic drug-induced agranulocytosis is a rare life-threatening adverse reaction characterised by an absolute neutrophil count <500 cells/µL of blood. Nitrofurantoin has been associated with haematological adverse events, but few agranulocytosis cases worldwide have been reported. We present a case of a 68-year-old woman who presented with fever and agranulocytosis following treatment with nitrofurantoin. Extensive workup for agranulocytosis, including a bone marrow aspirate, was unremarkable. Treatment with nitrofurantoin was discontinued, which led to a complete recovery of the complete blood count. This case stresses the importance of monitoring treatments, given that widely used drugs are not free from severe adverse reactions.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Neutropenia
/
Nitrofurantoin
Type of study:
Case report
Limits:
Aged
/
Female
/
Humans
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Bcr-2021-246788
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