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Nitrofurantoin-induced agranulocytosis.
Lopes, Vanessa; Ramos, Joana; Dias, Patrícia; Santos, Arsénio.
  • Lopes V; Cardiology Department, Centro Hospitalar e Universitário de Coimbra EPE, Coimbra, Portugal vlopes.pt@gmail.com.
  • Ramos J; Internal Medicine Department, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.
  • Dias P; Internal Medicine Department, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.
  • Santos A; Internal Medicine Department, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.
BMJ Case Rep ; 14(11)2021 Nov 11.
Article in English | MEDLINE | ID: covidwho-1515267
ABSTRACT
Idiosyncratic drug-induced agranulocytosis is a rare life-threatening adverse reaction characterised by an absolute neutrophil count <500 cells/µL of blood. Nitrofurantoin has been associated with haematological adverse events, but few agranulocytosis cases worldwide have been reported. We present a case of a 68-year-old woman who presented with fever and agranulocytosis following treatment with nitrofurantoin. Extensive workup for agranulocytosis, including a bone marrow aspirate, was unremarkable. Treatment with nitrofurantoin was discontinued, which led to a complete recovery of the complete blood count. This case stresses the importance of monitoring treatments, given that widely used drugs are not free from severe adverse reactions.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neutropenia / Nitrofurantoin Type of study: Case report Limits: Aged / Female / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Bcr-2021-246788

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neutropenia / Nitrofurantoin Type of study: Case report Limits: Aged / Female / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Bcr-2021-246788