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Myocardial deformation assessed by CMR in children after multisystem inflammatory syndrome (MIS-C).
Krupickova, Sylvia; Bautista-Rodriguez, Carles; Hatipoglu, Suzan; Kang, Heechan; Fraisse, Alain; Di Salvo, Giovanni; Piccinelli, Enrico; Rowlinson, Giselle; Lane, Mary; Altamar Bermejo, Ivan; Moscatelli, Sara; Wage, Rick; Mohiaddin, Raad; Pennell, Dudley J; Voges, Inga.
  • Krupickova S; Department of Paediatric Cardiology, Royal Brompton Hospital, London, UK; Cardiovascular Magnetic Resonance department, Royal Brompton Hospital, London, UK; National Heart and Lung Institute, Imperial College, London, UK. Electronic address: s.krupickova@rbht.nhs.uk.
  • Bautista-Rodriguez C; Department of Paediatric Cardiology, Royal Brompton Hospital, London, UK; National Heart and Lung Institute, Imperial College, London, UK.
  • Hatipoglu S; Cardiovascular Magnetic Resonance department, Royal Brompton Hospital, London, UK; National Heart and Lung Institute, Imperial College, London, UK.
  • Kang H; Department of Paediatric Cardiology, Royal Brompton Hospital, London, UK.
  • Fraisse A; Department of Paediatric Cardiology, Royal Brompton Hospital, London, UK; National Heart and Lung Institute, Imperial College, London, UK.
  • Di Salvo G; Department of Paediatric Cardiology, Royal Brompton Hospital, London, UK; National Heart and Lung Institute, Imperial College, London, UK.
  • Piccinelli E; Department of Paediatric Cardiology, Royal Brompton Hospital, London, UK.
  • Rowlinson G; Department of Paediatric Cardiology, Royal Brompton Hospital, London, UK.
  • Lane M; Department of Paediatric Cardiology, Royal Brompton Hospital, London, UK.
  • Altamar Bermejo I; Department of Paediatric Cardiology, Royal Brompton Hospital, London, UK; Cardiovascular Magnetic Resonance department, Royal Brompton Hospital, London, UK.
  • Moscatelli S; Department of Paediatric Cardiology, Royal Brompton Hospital, London, UK; Cardiovascular Magnetic Resonance department, Royal Brompton Hospital, London, UK.
  • Wage R; Cardiovascular Magnetic Resonance department, Royal Brompton Hospital, London, UK.
  • Mohiaddin R; Cardiovascular Magnetic Resonance department, Royal Brompton Hospital, London, UK; National Heart and Lung Institute, Imperial College, London, UK.
  • Pennell DJ; Cardiovascular Magnetic Resonance department, Royal Brompton Hospital, London, UK; National Heart and Lung Institute, Imperial College, London, UK.
  • Voges I; Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
Int J Cardiol ; 346: 105-106, 2022 01 01.
Article in English | MEDLINE | ID: covidwho-1516243
ABSTRACT

BACKGROUND:

Short-term sequelae of Multisystem Inflammatory Syndrome in Children (MIS-C), recently published by our institution, showed rapid improvement of the cardiac abnormalities within a few weeks after the onset of the disease. However, subtle residual abnormalities, affecting mainly the myocardial interstitium, were shown in some of the patients. The current study aimed to assess myocardial deformation with CMR shortly after MIS-C.

METHODS:

Sixty children were included into the study; 30 following MIS-C (onset-to-scan mean 27 days, SD 11) and 30 controls. Strain values were compared between patients and controls and additionally to published paediatric normal CMR values. U-Mann Whitney test was used for comparison of the myocardial deformation between patients and controls.

RESULTS:

Median age of the patients was 9.0 years (range 0.99-14.4) and controls 9.8 years (range 4.7-14.9). All conventional CMR parameters in patients were in normal range. Strain values were significantly lower in patients than in controls. When compared to published centile graphs, radial and circumferential global strain was within 2.5th and 97.5th centile in all patients. Eleven patients had global longitudinal strain between 2.5th centile and 50th centile, 1 patient was below 2.5th centile and all the others above 50th centile. Only 3 controls had global longitudinal strain between 2.5th centile and 50th centile, all other had higher strain.

CONCLUSIONS:

This study demonstrates that myocardial deformation indices measured by CMR are within normal range in the vast majority of the patients within a few weeks after the onset of MIS-C. However, when compared to healthy controls, all strain parameters were lower in patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ventricular Function, Left / Magnetic Resonance Imaging, Cine Type of study: Prognostic study Topics: Long Covid Limits: Adolescent / Child / Child, preschool / Humans / Infant Language: English Journal: Int J Cardiol Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ventricular Function, Left / Magnetic Resonance Imaging, Cine Type of study: Prognostic study Topics: Long Covid Limits: Adolescent / Child / Child, preschool / Humans / Infant Language: English Journal: Int J Cardiol Year: 2022 Document Type: Article