The revisited role of interleukin-1 alpha and beta in autoimmune and inflammatory disorders and in comorbidities.
Autoimmun Rev
; 20(4): 102785, 2021 Apr.
Article
in English
| MEDLINE | ID: covidwho-1517045
ABSTRACT
The interleukin (IL) 1 family of cytokines is noteworthy to have pleiotropic functions in inflammation and acquired immunity. Over the last decades, several progresses have been made in understanding the function and regulation of the prototypical inflammatory cytokine (IL-1) in human diseases. IL-1α and IL-1ß deregulated signaling causes devastating diseases manifested by severe acute or chronic inflammation. In this review, we examine and compare the key aspects of IL-1α and IL-1ß biology and regulation and discuss their importance in the initiation and maintenance of inflammation that underlie the pathology of many human diseases. We also report the current and ongoing inhibitors of IL-1 signaling, targeting IL-1α, IL-1ß, their receptor or other molecular compounds as effective strategies to prevent or treat the onset and progression of various inflammatory disorders.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Interleukin-1alpha
/
Inflammation
Limits:
Humans
Language:
English
Journal:
Autoimmun Rev
Journal subject:
Allergy and Immunology
Year:
2021
Document Type:
Article
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