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Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer.
Shapiro, Lauren C; Thakkar, Astha; Campbell, Sean T; Forest, Stefanie K; Pradhan, Kith; Gonzalez-Lugo, Jesus D; Quinn, Ryann; Bhagat, Tushar D; Choudhary, Gaurav S; McCort, Margaret; Sica, R Alejandro; Goldfinger, Mendel; Goel, Swati; Anampa, Jesus D; Levitz, David; Fromowitz, Ariel; Shah, Akash Pradip; Sklow, Charlotte; Alfieri, Gregory; Racine, Andrew; Wolgast, Lucia; Greenberger, Lee; Verma, Amit; Halmos, Balazs.
  • Shapiro LC; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Thakkar A; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Campbell ST; Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Forest SK; Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Pradhan K; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Gonzalez-Lugo JD; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Quinn R; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Bhagat TD; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Choudhary GS; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • McCort M; Division of Infectious Diseases, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Sica RA; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Goldfinger M; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Goel S; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Anampa JD; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Levitz D; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Fromowitz A; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Shah AP; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Sklow C; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Alfieri G; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Racine A; Department of Pediatrics, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Wolgast L; Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Greenberger L; The Leukemia & Lymphoma Society, Rye Brook, NY, USA.
  • Verma A; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: amit.verma@einsteinmed.org.
  • Halmos B; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: bahalmos@montefiore.org.
Cancer Cell ; 40(1): 3-5, 2022 01 10.
Article in English | MEDLINE | ID: covidwho-1517077
ABSTRACT
Anti-COVID-19 immunity dynamics were assessed in patients with cancer in a prospective clinical trial. Waning of immunity was detected 4-6 months post-vaccination with significant increases in anti-spike IgG titers after booster dosing, and 56% of seronegative patients seroconverted post-booster vaccination. Prior anti-CD20/BTK inhibitor therapy was associated with reduced vaccine efficacy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Immunization, Secondary / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Antibodies, Viral / Neoplasms Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Cancer Cell Journal subject: Neoplasms Year: 2022 Document Type: Article Affiliation country: J.ccell.2021.11.006

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Immunization, Secondary / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Antibodies, Viral / Neoplasms Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Cancer Cell Journal subject: Neoplasms Year: 2022 Document Type: Article Affiliation country: J.ccell.2021.11.006