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Increased Blood Monocytic Myeloid Derived Suppressor Cells but Low Regulatory T Lymphocytes in Patients with Mild COVID-19.
Jiménez-Cortegana, Carlos; Liró, Julia; Palazón-Carrión, Natalia; Salamanca, Elena; Sojo-Dorado, Jesús; de la Cruz-Merino, Luis; Pascual, Álvaro; Rodríguez-Baño, Jesús; Sánchez-Margalet, Víctor.
  • Jiménez-Cortegana C; Department of Medical Biochemistry and Molecular Biology, and Immunology, School of Medicine, Clinical Biochemistry Service, Virgen Macarena University Hospital, University of Seville, Seville, Spain.
  • Liró J; Department of Medical Biochemistry and Molecular Biology, and Immunology, School of Medicine, Clinical Biochemistry Service, Virgen Macarena University Hospital, University of Seville, Seville, Spain.
  • Palazón-Carrión N; Infectious Diseases, Microbiology and Preventive Medicine Unit, Virgen Macarena University Hospital/Departments of Medicine and Microbiology, University of Seville/Biomedicine Institute of Seville (IBiS), Seville, Spain.
  • Salamanca E; Clinical Oncology Service, Virgen Macarena University Hospital, University of Seville, Seville, Spain.
  • Sojo-Dorado J; Infectious Diseases, Microbiology and Preventive Medicine Unit, Virgen Macarena University Hospital/Departments of Medicine and Microbiology, University of Seville/Biomedicine Institute of Seville (IBiS), Seville, Spain.
  • de la Cruz-Merino L; Infectious Diseases, Microbiology and Preventive Medicine Unit, Virgen Macarena University Hospital/Departments of Medicine and Microbiology, University of Seville/Biomedicine Institute of Seville (IBiS), Seville, Spain.
  • Pascual Á; Clinical Oncology Service, Virgen Macarena University Hospital, University of Seville, Seville, Spain.
  • Rodríguez-Baño J; Infectious Diseases, Microbiology and Preventive Medicine Unit, Virgen Macarena University Hospital/Departments of Medicine and Microbiology, University of Seville/Biomedicine Institute of Seville (IBiS), Seville, Spain.
  • Sánchez-Margalet V; Infectious Diseases, Microbiology and Preventive Medicine Unit, Virgen Macarena University Hospital/Departments of Medicine and Microbiology, University of Seville/Biomedicine Institute of Seville (IBiS), Seville, Spain.
Viral Immunol ; 34(9): 639-645, 2021 11.
Article in English | MEDLINE | ID: covidwho-1517820
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may produce a systemic disease, the coronavirus disease-19 (COVID-19), with high morbidity and mortality. Even though we do not fully understand the interaction of innate and adaptive immunity in the control and complications of the viral infection, it is well recognized that SARS-CoV-2 induces an immunodepression that impairs the elimination of the virus and favors its rapid dissemination in the organism. Even less is known about the possible participation of inhibitory cells of the innate immune system, such as the myeloid-derived suppressor cells (MDSCs), or the adaptive immune system, such as the T regulatory cells (Tregs). That is why we aimed to study blood levels of MDSCs, as well as lymphocyte subpopulations, including Tregs, and activated (OX-40+) and inhibited (PD-1) T lymphocytes in patients with mild COVID-19 in comparison with data obtained from control donors. We have found that 20 hospitalized patients with COVID-19 and no health history of immunosuppression had a significant increase in the number of peripheral monocytic MDSCs (M-MDSC), but a decrease in Tregs, as well as an increase in the number of inhibited or exhausted T cells, whereas the number of activated T cells was significantly decreased compared with that from 20 healthy controls. Moreover, there was a significant negative correlation (r = 0.496) between the number of M-MDSC and the number of activated T cells. Therefore, M-MDSC rather than Tregs may contribute to the immunosuppression observed in patients with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: T-Lymphocytes, Regulatory / Myeloid-Derived Suppressor Cells / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Variants Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Viral Immunol Journal subject: Allergy and Immunology / Virology Year: 2021 Document Type: Article Affiliation country: Vim.2021.0044

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Full text: Available Collection: International databases Database: MEDLINE Main subject: T-Lymphocytes, Regulatory / Myeloid-Derived Suppressor Cells / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Variants Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Viral Immunol Journal subject: Allergy and Immunology / Virology Year: 2021 Document Type: Article Affiliation country: Vim.2021.0044