Antiviral peptide engineering for targeting membrane-enveloped viruses: Recent progress and future directions.
Biochim Biophys Acta Biomembr
; 1864(2): 183821, 2022 02 01.
Article
in English
| MEDLINE | ID: covidwho-1519618
ABSTRACT
Membrane-enveloped viruses are a major cause of global health challenges, including recent epidemics and pandemics. This mini-review covers the latest efforts to develop membrane-targeting antiviral peptides that inhibit enveloped viruses by 1) preventing virus-cell fusion or 2) disrupting the viral membrane envelope. The corresponding mechanisms of antiviral activity are discussed along with peptide engineering strategies to modulate membrane-peptide interactions in terms of potency and selectivity. Application examples are presented demonstrating how membrane-targeting antiviral peptides are useful therapeutics and prophylactics in animal models, while a stronger emphasis on biophysical concepts is proposed to refine mechanistic understanding and support potential clinical translation.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Peptide Fragments
/
Viruses
/
Cell Membrane
/
Virus Internalization
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Biochim Biophys Acta Biomembr
Year:
2022
Document Type:
Article
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