Clearance of Lormetazepam, Midazolam, and Their Conjugated Metabolites by Continuous Venovenous Hemofiltration During Prolonged Sedation in Critically Ill Patients With COVID-19-Associated Acute Respiratory Distress Syndrome.

Shudofsky, Kimberly N; Janssen, Paddy K C; Foudraine, Norbert; le Noble, Jos L M L

Shudofsky, Kimberly N; Janssen, Paddy K C; Foudraine, Norbert; le Noble, Jos L M L.

Shudofsky KN; Department of Clinical Pharmacy, VieCuri Medical Center, Venlo, The Netherlands.
Janssen PKC; Department of Clinical Pharmacy, VieCuri Medical Center, Venlo, The Netherlands.
Foudraine N; Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Center, Maastricht, The Netherlands.
le Noble JLML; Department of Intensive Care, VieCuri Medical Center, Venlo, The Netherlands.

J Clin Pharmacol ; 62(4): 568-570, 2022 04.

Article in English | MEDLINE | ID: covidwho-1520231

Subject(s)

COVID-19 Drug Treatment; Deep Sedation; Hypnotics and Sedatives/metabolism; Hypnotics and Sedatives/pharmacokinetics; Lorazepam/analogs & derivatives; Midazolam/metabolism; Midazolam/pharmacokinetics; Respiratory Distress Syndrome/drug therapy; Aged; COVID-19/complications; Continuous Renal Replacement Therapy; Critical Illness/therapy; Humans; Hypnotics and Sedatives/therapeutic use; Lorazepam/metabolism; Lorazepam/pharmacokinetics; Lorazepam/therapeutic use; Male; Midazolam/therapeutic use; Middle Aged; Respiratory Distress Syndrome/complications

Keywords

COVID-19; Conjugated metabolites; Continuous venovenous hemofiltration; Lormetazepam; Midazolam; Prolonged sedation

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Midazolam / Deep Sedation / COVID-19 Drug Treatment / Hypnotics and Sedatives / Lorazepam Topics: Long Covid Limits: Aged / Humans / Male / Middle aged Language: English Journal: J Clin Pharmacol Year: 2022 Document Type: Article Affiliation country: Jcph.2005

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