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Critical analysis of acute kidney injury in pediatric COVID-19 patients in the intensive care unit.
Raina, Rupesh; Chakraborty, Ronith; Mawby, Isabelle; Agarwal, Nirav; Sethi, Sidharth; Forbes, Michael.
  • Raina R; Department of Nephrology, Akron Nephrology Associates/Cleveland Clinic Akron General, Akron, OH, USA. rraina@akronchildrens.org.
  • Chakraborty R; Department of Nephrology, Akron Children's Hospital, Akron, OH, USA. rraina@akronchildrens.org.
  • Mawby I; School of Medicine, Case Western Reserve University, Cleveland, OH, USA. rraina@akronchildrens.org.
  • Agarwal N; Department of Nephrology, Akron Nephrology Associates/Cleveland Clinic Akron General, Akron, OH, USA.
  • Sethi S; Department of Nephrology, Akron Children's Hospital, Akron, OH, USA.
  • Forbes M; Department of Nephrology, Akron Nephrology Associates/Cleveland Clinic Akron General, Akron, OH, USA.
Pediatr Nephrol ; 36(9): 2627-2638, 2021 09.
Article in English | MEDLINE | ID: covidwho-1520348
ABSTRACT
BACKGROUND AND

OBJECTIVES:

COVID-19 is responsible for the 2019 novel coronavirus disease pandemic. Despite the vast research about the adult population, there has been little data collected on acute kidney injury (AKI) epidemiology, associated risk factors, treatments, and mortality in pediatric COVID-19 patients admitted to the ICU. AKI is a severe complication of COVID-19 among children and adolescents.

METHODS:

A comprehensive literature search was conducted in PubMed/MEDLINE and Cochrane Center Trials to find all published literature related to AKI in COVID-19 patients, including incidence and outcomes.

RESULTS:

Twenty-four studies reporting the outcomes of interest were included. Across all studies, the overall sample size of COVID positive children was 1,247 and the median age of this population was 9.1 years old. Among COVID positive pediatric patients, there was an AKI incidence of 30.51%, with only 0.56% of these patients receiving KRT. The mortality was 2.55% among all COVID positive pediatric patients. The incidence of multisystem inflammatory syndrome in children (MIS-C) among COVID positive patients was 74.29%.

CONCLUSION:

AKI has shown to be a negative prognostic factor in adult patients with COVID-19 and now also in the pediatric cohort with high incidence and mortality rates. Additionally, our findings show a strong comparison in epidemiology between adult and pediatric COVID-19 patients; however, they need to be confirmed with additional data and studies.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Renal Replacement Therapy / Systemic Inflammatory Response Syndrome / Acute Kidney Injury / COVID-19 / Intensive Care Units Subject: Renal Replacement Therapy / Systemic Inflammatory Response Syndrome / Acute Kidney Injury / COVID-19 / Intensive Care Units Type of study: Diagnostic study / Etiology study / Incidence study / Prognostic study / Risk factors / Systematic review Language: English Journal: Pediatr Nephrol Clinical aspect: Etiology / Prognosis Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Renal Replacement Therapy / Systemic Inflammatory Response Syndrome / Acute Kidney Injury / COVID-19 / Intensive Care Units Subject: Renal Replacement Therapy / Systemic Inflammatory Response Syndrome / Acute Kidney Injury / COVID-19 / Intensive Care Units Type of study: Diagnostic study / Etiology study / Incidence study / Prognostic study / Risk factors / Systematic review Language: English Journal: Pediatr Nephrol Clinical aspect: Etiology / Prognosis Year: 2021
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