Your browser doesn't support javascript.
Evaluation of SARS-CoV-2 antibody responses in healthcare workers at a tertiary care COVID 19 dedicated hospital in Delhi.
Sherwal, B L; Bhattar, Sonali; Sabharwal, Sukriti; Jain, Ajeet; Saxena, Shikhar; Bargotya, Mona; Dogra, Vikas.
  • Sherwal BL; Rajiv Gandhi Super Speciality Hospital, Tahirpur, Delhi 110091, India.
  • Bhattar S; Rajiv Gandhi Super Speciality Hospital, Tahirpur, Delhi 110091, India. Electronic address: drsonalivds1@gmail.com.
  • Sabharwal S; Rajiv Gandhi Super Speciality Hospital, Tahirpur, Delhi 110091, India.
  • Jain A; Rajiv Gandhi Super Speciality Hospital, Tahirpur, Delhi 110091, India.
  • Saxena S; Rajiv Gandhi Super Speciality Hospital, Tahirpur, Delhi 110091, India.
  • Bargotya M; Rajiv Gandhi Super Speciality Hospital, Tahirpur, Delhi 110091, India.
  • Dogra V; Rajiv Gandhi Super Speciality Hospital, Tahirpur, Delhi 110091, India.
Indian J Med Microbiol ; 40(1): 30-34, 2022.
Article in English | MEDLINE | ID: covidwho-1521053
ABSTRACT

PURPOSE:

Amidst the on-going SARS-CoV-2 pandemic, healthcare workers have been at a greater risk of disease exposure as they are working in environments chiefly involved in the COVID-19 patient care since March 2020. SARS-CoV-2 antibody testing can prove to be a valuable tool for better understanding of prevalence of disease exposure in this population. Therefore, we conducted this study to grasp the sero-prevalence of COVID-19 antibodies in our hospital to better comprehend the duration of IgG response.

METHODS:

This was a longitudinal study involving 305 healthcare workers at Rajiv Gandhi Super Speciality Hospital spanning over a period of four months starting from October 2020 to January 2021. Serum samples were obtained from the study group taken as Day 0 of the study and were screened for the presence of SARS-CoV-2 IgG antibodies using semi-quantitive enzyme linked immunoassay technology from ERBAlisa (India). The Antibody Index was determined. Those showing reactive in the screening test were further followed up on a monthly basis till January 2021 for serial antibody testing.

RESULTS:

The overall seroprevalence for IgG response among the workers was found to be 21.96%. Seropositivity rate was observed to be significantly higher in those having a history of RT-PCR confirmed COVID-19 infection (45.09%)

CONCLUSIONS:

Our study demonstrated that healthcare workers have a higher sero-prevalence. Our study also demonstrated that the antibodies developed following COVID-19 infection had a waning effect of protective response following infection.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Indian J Med Microbiol Journal subject: Microbiology Year: 2022 Document Type: Article Affiliation country: J.ijmmb.2021.11.006

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Indian J Med Microbiol Journal subject: Microbiology Year: 2022 Document Type: Article Affiliation country: J.ijmmb.2021.11.006