SARS-CoV-2 seroprevalence in the city of Hyderabad, India in early 2021.
IJID Reg
; 2: 1-7, 2022 Mar.
Article
in English
| MEDLINE | ID: covidwho-1521056
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
ABSTRACT
Background:
COVID-19 emerged as a global pandemic in 2020, spreading rapidly to most parts of the world. The proportion of infected individuals in a population can be reliably estimated via serosurveillance, making it a valuable tool for planning control measures. Our serosurvey study aimed to investigate SARS-CoV-2 seroprevalence in the urban population of Hyderabad at the end of the first wave of infections.Methods:
This cross-sectional survey, conducted in January 2021 and including males and females aged 10 years and above, used multi-stage random sampling. 9363 samples were collected from 30 wards distributed over six zones of Hyderabad, and tested for antibodies against SARS-CoV-2 nucleocapsid antigen.Results:
Overall seropositivity was 54.2%, ranging from 50% to 60% in most wards. Highest exposure appeared to be among those aged 30-39 and 50-59 years, with women showing greater seropositivity. Seropositivity increased with family size, with only marginal differences among people with varying levels of education. Seroprevalence was significantly lower among smokers. Only 11% of the survey subjects reported any COVID-19 symptoms, while 17% had appeared for COVID-19 testing.Conclusion:
Over half the city's population was infected within a year of onset of the pandemic. However, â¼ 46% of people remained susceptible, contributing to subsequent waves of infection.
ACE2, angiotensin-converting enzyme 2; CCMB, Centre for Cellular and Molecular Biology; CI, confidence interval; COI, cutoff index; COVID-19; COVID-19, coronavirus disease; CSIR, Council of Scientific and Industrial Research; GHMC, Greater Hyderabad Municipal Corporation; Hyderabad; ICMR, Indian Council of Medical Research; India; NIN, National Institute of Nutrition; ODK, Open Data Kit; RT-PCR, reverse-transcription polymerase chain reaction; SARS, severe acute respiratory syndrome; SARS-CoV-2 antibody; SD, standard deviation; SPSS, Statistical Package for the Social Sciences; seroprevalence; serosurveillance
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Observational study
/
Randomized controlled trials
Language:
English
Journal:
IJID Reg
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS