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Post-COVID-19 interstitial lung disease presenting with profound hypoxemia: Report of three cases demonstrating a good response to high-dose corticosteroid therapy.
Uemasu, Kiyoshi; Yasuda, Yuto; Hirayama, Yutaka; Arasawa, Soichi; Iwashima, Daisuke; Takahashi, Ken-Ichi.
  • Uemasu K; Department of Respiratory Medicine, Kishiwada City Hospital, Japan. Electronic address: kuemasu@kuhp.kyoto-u.ac.jp.
  • Yasuda Y; Department of Respiratory Medicine, Kishiwada City Hospital, Japan.
  • Hirayama Y; Department of Respiratory Medicine, Kishiwada City Hospital, Japan.
  • Arasawa S; Department of Gastroenterology, Kishiwada City Hospital, Japan.
  • Iwashima D; Department of Respiratory Medicine, Kishiwada City Hospital, Japan.
  • Takahashi KI; Department of Respiratory Medicine, Kishiwada City Hospital, Japan.
J Infect Chemother ; 28(2): 321-325, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1521285
ABSTRACT
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which leads to critical pneumonia, although the clinical courses vary. In some cases, COVID-19 pneumonia causes secondary pulmonary fibrosis, which can retain radiological changes and prolong respiratory symptoms. Interstitial lung disease (ILD) secondary to COVID-19 is thought to be caused by multiple pathologies, such as excessive cytokines and abnormal repair processes elaborated by lung cells (epithelium, mesenchyme, and alveolar macrophages) after lung injury rather than viral invasion itself. Immunosuppression therapy may improve chronic respiratory symptoms and radiological changes in post-COVID-19 ILD, although the treatment is not yet established. Herein, we report three patients with post-COVID-19 ILD who presented with profound hypoxemia that had a good response to high-dose corticosteroid therapy. Further and larger studies are needed to establish post-COVID-19 ILD.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Lung Diseases, Interstitial / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: J Infect Chemother Journal subject: Microbiology / Drug Therapy Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Lung Diseases, Interstitial / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: J Infect Chemother Journal subject: Microbiology / Drug Therapy Year: 2022 Document Type: Article