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The Turkish experience of COVID-19 infection in people with NMOSD and MOGAD: A milder course?
Sen, Sedat; Tuncer, Asli; Ozakbas, Serkan; Uzunkopru, Cihat; Baba, Cavid; Demir, Serkan; Beckmann, Yesim; Gumus, Haluk; Arslan, Gokhan; Kilic, Ahmet Kasim; Altintas, Ayse; Yuceyar, Nur; Turan, Omer Faruk; Tutuncu, Melih; Terzi, Murat; Acar, Pinar; Bunul, Sena Destan; Balci, Belgin Petek; Bir, Levent Sinan; Koseoglu, Mesrure; Mungan, Semra; Gunduz, Tuncay; Dogan, Ipek Gungor; Kotan, Dilcan; Uygunoglu, Ugur; Ekmekci, Ozgul; Demirkiran, Meltem; Kamisli, Ozden; Kabay, Sibel Canbaz; Tamam, Yusuf; Omerhoca, Sami; Sevim, Serhan; Guler, Sibel; Kurtuncu, Murat; Efendi, Husnu; Karabudak, Rana; Siva, Aksel.
  • Sen S; Ondokuz Mayis University School of Medicine Samsun, Turkey. Electronic address: Sedatsen83@hotmail.com.
  • Tuncer A; Hacettepe University School of Medicine Ankara, Turkey.
  • Ozakbas S; Dokuz Eylul University School of Medicine Izmir, Turkey.
  • Uzunkopru C; Katip Celebi University School of Medicine Izmir, Turkey.
  • Baba C; Dokuz Eylul University School of Medicine Izmir, Turkey.
  • Demir S; Sancaktepe Sehit Prof. Dr. Ilhan Varank Research and Training Hospital, Istanbul, Turkey.
  • Beckmann Y; Katip Celebi University School of Medicine Izmir, Turkey.
  • Gumus H; Selcuk University School of Medicine Konya, Turkey.
  • Arslan G; Ondokuz Mayis University School of Medicine Samsun, Turkey.
  • Kilic AK; Kartal Dr. Lutfi Kirdar Research and Training Hospital, Istanbul, Turkey.
  • Altintas A; Koc University School of Medicine, Istanbul, Turkey.
  • Yuceyar N; Ege University School of Medicine, Izmir, Turkey.
  • Turan OF; Uludag University School of Medicine Bursa, Turkey.
  • Tutuncu M; Istanbul University Cerrahpasa School of Medicine Istanbul, Turkey.
  • Terzi M; Ondokuz Mayis University School of Medicine Samsun, Turkey.
  • Acar P; Hacettepe University School of Medicine Ankara, Turkey.
  • Bunul SD; Kocaeli University School of Medicine Kocaeli, Turkey.
  • Balci BP; Haseki Research and Training Hospital, Istanbul, Turkey.
  • Bir LS; Pamukkale University School of Medicine Denizli, Turkey.
  • Koseoglu M; Bakirkoy Prof. Dr. Mashar Osman Research and Training Hospital, Istanbul, Turkey.
  • Mungan S; Ankara City Hospital, Neurology Clinic, Ankara, Turkey.
  • Gunduz T; Istanbul University Istanbul School of Medicine Istanbul, Turkey.
  • Dogan IG; Sancaktepe Sehit Prof. Dr. Ilhan Varank Research and Training Hospital, Istanbul, Turkey.
  • Kotan D; Sakarya Research and Training Hospital, Sakarya, Turkey.
  • Uygunoglu U; Istanbul University Cerrahpasa School of Medicine Istanbul, Turkey.
  • Ekmekci O; Ege University School of Medicine, Izmir, Turkey.
  • Demirkiran M; Cukurova University School of Medicine Adana, Turkey.
  • Kamisli O; Inonu University School of Medicine Malatya, Turkey.
  • Kabay SC; Kutahya Health Sciences University School of Medicine, Kutahya, Turkey.
  • Tamam Y; Dicle University School of Medicine Diyarbakir, Turkey.
  • Omerhoca S; Bagcilar Research and Training Hospital, Istanbul, Turkey.
  • Sevim S; Mersin University School of Medicine, Mersin, Turkey.
  • Guler S; Trakya University School of Medicine, Edirne, Turkey.
  • Kurtuncu M; Istanbul University Istanbul School of Medicine Istanbul, Turkey.
  • Efendi H; Kocaeli University School of Medicine Kocaeli, Turkey.
  • Karabudak R; Hacettepe University School of Medicine Ankara, Turkey.
  • Siva A; Istanbul University Cerrahpasa School of Medicine Istanbul, Turkey. Electronic address: akselsiva@gmail.com.
Mult Scler Relat Disord ; 58: 103399, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1521425
ABSTRACT

BACKGROUND:

COVID-19 is a multisystemic infection with variables consequences depending on individual and comorbid conditions. The course and outcomes of COVID-19 during neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD) are not clearly known. OBJECTIVE/

METHODS:

The aim of this study was to examine the features and outcomes of COVID-19 infection in NMOSD and MOGAD patients. The patients' demographic and clinical factors, disease modifying treatment (DMT) used and disease information of COVID-19 infection were recorded. Conditions leading to hospitalization and severe exposure to COVID-19 infection were also analyzed.

RESULTS:

The study included 63 patients from 25 centers. Thirty-two patients (50.8%) belong to AQP-4 seropositive group, 13 (20.6%) and 18 (28.6%) were in MOG-positive and double-seronegative groups, respectively. Risk factors for severe COVID-19 infection and hospitalization were advanced age, high disability level and the presence of comorbid disease. Disease severity was found to be high in double-seronegative NMOSD and low in MOGAD patients. No statistically significant effect of DMTs on disease severity and hospitalization was found.

CONCLUSION:

In NMOSD and MOGAD patients, advanced age, high disability and presence of comorbid disease pose risks for severe COVID-19 infection. There was no direct significant effect of DMTs for COVID-19 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neuromyelitis Optica / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Mult Scler Relat Disord Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neuromyelitis Optica / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Mult Scler Relat Disord Year: 2022 Document Type: Article