Your browser doesn't support javascript.
The extent of neuroradiological findings in COVID-19 shows correlation with blood biomarkers, Glasgow coma scale score and days in intensive care.
Fällmar, David; Rostami, Elham; Kumlien, Eva; Ashton, Nicholas J; Jackmann, Sven; Pavel, Radu; Blennow, Kaj; Hultström, Michael; Lipcsey, Miklos; Frithiof, Robert; Westman, Gabriel; Zetterberg, Henrik; Wikström, Johan; Virhammar, Johan.
  • Fällmar D; Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden. Electronic address: david.fallmar@akademiska.se.
  • Rostami E; Department of Neuroscience, Neurosurgery, Uppsala University, Uppsala, Sweden.
  • Kumlien E; Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden.
  • Ashton NJ; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden; Institute of Psychiatry, Psycho
  • Jackmann S; Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden.
  • Pavel R; Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden.
  • Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
  • Hultström M; Department of Surgical Sciences, Anaesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Medical Cell Biology, Integrative Physiology, Uppsala University, Uppsala, Sweden.
  • Lipcsey M; Department of Surgical Sciences, Anaesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden; Hedenstierna Laboratory, CIRRUS, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
  • Frithiof R; Department of Surgical Sciences, Anaesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden.
  • Westman G; Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, Uppsala, Sweden.
  • Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease, UCL Instit
  • Wikström J; Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden.
  • Virhammar J; Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden.
J Neuroradiol ; 2021 Nov 18.
Article in English | MEDLINE | ID: covidwho-1521436
ABSTRACT
BACKGROUND AND

PURPOSE:

A wide range of neuroradiological findings has been reported in patients with coronavirus disease 2019 (COVID-19), ranging from subcortical white matter changes to infarcts, haemorrhages and focal contrast media enhancement. These have been descriptively but inconsistently reported and correlations with clinical findings and biomarkers have been difficult to extract from the literature. The purpose of this study was to quantify the extents of neuroradiological findings in a cohort of patients with COVID-19 and neurological symptoms, and to investigate correlations with clinical findings, duration of intensive care and biomarkers in blood. MATERIAL AND

METHODS:

Patients with positive SARS-CoV-2 and at least one new-onset neurological symptom were included from April until July 2020. Nineteen patients were examined regarding clinical symptoms, biomarkers in blood and MRI of the brain. In order to quantify the MRI findings, a semi-quantitative neuroradiological severity scale was constructed a priori, and applied to the MR images by two specialists in neuroradiology. RESULTS AND

CONCLUSIONS:

The score from the severity scale correlated significantly with blood biomarkers of CNS injury (glial fibrillary acidic protein, total-tau, ubiquitin carboxyl-terminal hydrolase L1) and inflammation (C-reactive protein), Glasgow Coma Scale score, and the number of days spent in intensive care. The underlying radiological assessments had inter-rater agreements of 90.5%/86% (for assessments with 2/3 alternatives). Total intraclass correlation was 0.80. Previously reported neuroradiological findings in COVID-19 have been diverse and heterogenous. In this study, the extent of findings in MRI examination of the brain, quantified using a structured report, shows correlation with relevant biomarkers.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study Language: English Year: 2021 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study Language: English Year: 2021 Document Type: Article