Your browser doesn't support javascript.
Evaluation of serum total sialic acid in moderate COVID-19 patients with and without gastrointestinal tract manifestations.
Haroun, Riham Abdel-Hamid; Osman, Waleed H; Eessa, Asmaa M.
  • Haroun RA; Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt. Electronic address: riham.haroun@sci.asu.edu.eg.
  • Osman WH; Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.
  • Eessa AM; Department of Geriatric Medicine and Gerontology, Faculty of Medicine, Port-Said University, Port-Said, Egypt.
Tissue Cell ; 74: 101679, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1521561
ABSTRACT

BACKGROUND:

It is known that SARS-CoV-2 mostly infects the respiratory system causing pneumonia; although it can also affect the gastrointestinal tract (GIT), which covered with a bi-layer of mucus rich in glycosylated proteins that terminated by sialic acid. Therefore; this study aimed to evaluate serum total sialic acid (TSA) in moderate COVID-19 patients with and without GIT manifestations.

METHODS:

A total of 161 moderate COVID-19 patients without and with GIT manifestations and 50 controls were enrolled into our study. Serum electrolytes levels were measured by using colorimetric or turbidmetric commercial assay kits, while the level of serum TSA was measured by using a commercial ELISA kit.

RESULTS:

Our results showed that serum TSA level was highly significantly increased in moderate COVID-19 patients with GIT manifestations (81.43 ± 8.91) when compared with controls (61.24 ± 6.41) or even moderate COVID-19 patients without GIT manifestations (69.46 ± 7.03). ROC curve analysis showed that AUC for TSA is 0.84 with 76.2 % sensitivity and 73.7 % specificity in discrimination between moderate COVID-19 patients with and without GIT manifestations. Serum potassium and sodium levels were highly significantly decreased in moderate COVID-19 patients with GIT manifestations when compared with controls or even moderate COVID-19 patients without GIT manifestations; while serum calcium level was found to be significantly decreased in moderate COVID-19 patients with GIT manifestations when compared with controls.

CONCLUSION:

Finally, we can conclude that SA plays a crucial role in the pathogenesis of GIT complications associated with COVID-19 and could be a potential biomarker for the COVID-19 gastrointestinal complications.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: N-Acetylneuraminic Acid / Gastrointestinal Tract / COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Tissue Cell Year: 2022 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: N-Acetylneuraminic Acid / Gastrointestinal Tract / COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Tissue Cell Year: 2022 Document Type: Article