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The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2.
Foo, Suan-Sin; Cambou, Mary Catherine; Mok, Thalia; Fajardo, Viviana M; Jung, Kyle L; Fuller, Trevon; Chen, Weiqiang; Kerin, Tara; Mei, Jenny; Bhattacharya, Debika; Choi, Younho; Wu, Xin; Xia, Tian; Shin, Woo-Jin; Cranston, Jessica; Aldrovandi, Grace; Tobin, Nicole; Contreras, Deisy; Ibarrondo, Francisco J; Yang, Otto; Yang, Shangxin; Garner, Omai; Cortado, Ruth; Bryson, Yvonne; Janzen, Carla; Ghosh, Shubhamoy; Devaskar, Sherin; Asilnejad, Brenda; Moreira, Maria Elisabeth; Vasconcelos, Zilton; Soni, Priya R; Gibson, L Caroline; Brasil, Patricia; Comhair, Suzy A A; Arumugaswami, Vaithilingaraja; Erzurum, Serpil C; Rao, Rashmi; Jung, Jae U; Nielsen-Saines, Karin.
  • Foo SS; Department of Cancer Biology, Infection Biology Program, and Global Center for Pathogen Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Cambou MC; Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Mok T; Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Fajardo VM; Department of Pediatrics, Division of Neonatology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Jung KL; Department of Cancer Biology, Infection Biology Program, and Global Center for Pathogen Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Fuller T; Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Manguinhos, Rio de Janeiro 21040-360, Brazil.
  • Chen W; Department of Cancer Biology, Infection Biology Program, and Global Center for Pathogen Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Kerin T; Department of Pediatrics, Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Mei J; Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Bhattacharya D; Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Choi Y; Department of Cancer Biology, Infection Biology Program, and Global Center for Pathogen Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Wu X; Department of Cancer Biology, Infection Biology Program, and Global Center for Pathogen Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Xia T; Department of Cancer Biology, Infection Biology Program, and Global Center for Pathogen Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Shin WJ; Department of Cancer Biology, Infection Biology Program, and Global Center for Pathogen Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Cranston J; Department of Pediatrics, Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Aldrovandi G; Department of Pediatrics, Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Tobin N; Department of Pediatrics, Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Contreras D; Department of Pediatrics, Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Ibarrondo FJ; Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Yang O; Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Yang S; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Garner O; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Cortado R; Department of Pediatrics, Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Bryson Y; Department of Pediatrics, Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Janzen C; Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Ghosh S; Department of Pediatrics, Division of Neonatology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Devaskar S; Department of Pediatrics, Division of Neonatology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Asilnejad B; Georgetown University School of Medicine, Washington, DC 20007, USA.
  • Moreira ME; Instituto Fernades Figueira, Fiocruz, Flamengo, Rio de Janeiro 20140-360, Brazil.
  • Vasconcelos Z; Instituto Fernades Figueira, Fiocruz, Flamengo, Rio de Janeiro 20140-360, Brazil.
  • Soni PR; Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA 90049, USA.
  • Gibson LC; Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA 90049, USA.
  • Brasil P; Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Manguinhos, Rio de Janeiro 21040-360, Brazil.
  • Comhair SAA; Respiratory Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Arumugaswami V; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Erzurum SC; Respiratory Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Rao R; Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Jung JU; Department of Cancer Biology, Infection Biology Program, and Global Center for Pathogen Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Nielsen-Saines K; Department of Pediatrics, Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Cell Rep Med ; 2(11): 100453, 2021 11 16.
Article in English | MEDLINE | ID: covidwho-1521606
ABSTRACT
While pregnancy increases the risk for severe COVID-19, the clinical and immunological implications of COVID-19 on maternal-fetal health remain unknown. Here, we present the clinical and immunological landscapes of 93 COVID-19 mothers and 45 of their SARS-CoV-2-exposed infants through comprehensive serum proteomics profiling for >1,400 cytokines of their peripheral and cord blood specimens. Prenatal SARS-CoV-2 infection triggers NF-κB-dependent proinflammatory immune activation. Pregnant women with severe COVID-19 show increased inflammation and unique IFN-λ antiviral signaling, with elevated levels of IFNL1 and IFNLR1. Furthermore, SARS-CoV-2 infection re-shapes maternal immunity at delivery, altering the expression of pregnancy complication-associated cytokines, inducing MMP7, MDK, and ESM1 and reducing BGN and CD209. Finally, COVID-19-exposed infants exhibit induction of T cell-associated cytokines (IL33, NFATC3, and CCL21), while some undergo IL-1ß/IL-18/CASP1 axis-driven neonatal respiratory distress despite birth at term. Our findings demonstrate COVID-19-induced immune rewiring in both mothers and neonates, warranting long-term clinical follow-up to mitigate potential health risks.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokines / Proteomics / COVID-19 / Inflammation Type of study: Cohort study / Prognostic study Limits: Adolescent / Adult / Female / Humans / Infant, Newborn / Pregnancy / Young adult Language: English Journal: Cell Rep Med Year: 2021 Document Type: Article Affiliation country: J.xcrm.2021.100453

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokines / Proteomics / COVID-19 / Inflammation Type of study: Cohort study / Prognostic study Limits: Adolescent / Adult / Female / Humans / Infant, Newborn / Pregnancy / Young adult Language: English Journal: Cell Rep Med Year: 2021 Document Type: Article Affiliation country: J.xcrm.2021.100453