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Estimation of SARS-CoV-2 Infection Fatality Rate by Age and Comorbidity Status Using Antibody Screening of Blood Donors During the COVID-19 Epidemic in Denmark.
Kaspersen, Kathrine Agergård; Hindhede, Lotte; Boldsen, Jens Kjærgaard; Mikkelsen, Susan; Vestergaard, Lasse Skafte; Berthelsen, Ann-Sofie Nicole; Moustsen-Helms, Ida Rask; Holm, Dorte Kinggaard; Nilsson, Anna Christine; Sækmose, Susanne Gjørup; Sørensen, Erik; Harritshøj, Lene Holm; Aagaard, Bitten; Hjalgrim, Henrik; Lillevang, Søren Thue; Jørgensen, Charlotte Sværke; Krause, Tyra Grove; Ullum, Henrik; Pedersen, Ole Birger Vestager; Ostrowski, Sisse Rye; Erikstrup, Christian.
  • Kaspersen KA; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
  • Hindhede L; Danish Big Data Centre for Environment and Health, Aarhus University, Roskilde, Denmark.
  • Boldsen JK; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
  • Mikkelsen S; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
  • Vestergaard LS; Danish Big Data Centre for Environment and Health, Aarhus University, Roskilde, Denmark.
  • Berthelsen AN; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
  • Moustsen-Helms IR; Infectious Disease Preparedness, Statens Serum Institut, Copenhagen, Denmark.
  • Holm DK; Infectious Disease Preparedness, Statens Serum Institut, Copenhagen, Denmark.
  • Nilsson AC; Infectious Disease Preparedness, Statens Serum Institut, Copenhagen, Denmark.
  • Sækmose SG; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.
  • Sørensen E; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.
  • Harritshøj LH; Department of Clinical Immunology, Zealand University Hospital, Naestved, Denmark.
  • Aagaard B; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.
  • Hjalgrim H; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.
  • Lillevang ST; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark.
  • Jørgensen CS; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
  • Krause TG; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.
  • Ullum H; Department of Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark.
  • Pedersen OBV; Infectious Disease Preparedness, Statens Serum Institut, Copenhagen, Denmark.
  • Ostrowski SR; Statens Serums Institut, Copenhagen, Denmark.
  • Erikstrup C; Department of Clinical Immunology, Zealand University Hospital, Naestved, Denmark.
J Infect Dis ; 225(2): 219-228, 2022 01 18.
Article in English | MEDLINE | ID: covidwho-1522221
ABSTRACT

BACKGROUND:

Studies presenting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) for healthy individuals are warranted. We estimate IFR by age and comorbidity status using data from a large serosurvey among Danish blood donors and nationwide data on coronavirus disease 2019 (COVID-19) mortality.

METHODS:

Danish blood donors aged 17-69 years donating blood October 2020-February 2021 were tested with a commercial SARS-CoV-2 total antibody assay. IFR was estimated for weeks 11 to 42, 2020 and week 43, 2020 to week 6, 2021, representing the first 2 waves of COVID-19 epidemic in Denmark.

RESULTS:

In total, 84944 blood donors were tested for antibodies. The seroprevalence was 2% in October 2020 and 7% in February 2021. Among 3898039 Danish residents aged 17-69 years, 249 deaths were recorded. The IFR was low for people <51 years without comorbidity during the 2 waves (combined IFR=3.36 per 100000 infections). The IFR was below 3‰ for people aged 61-69 years without comorbidity. IFR increased with age and comorbidity but declined from the first to second wave.

CONCLUSIONS:

In this nationwide study, the IFR was very low among people <51 years without comorbidity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Donors / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Screening study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Donors / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Screening study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis