The Emergence of the Spike Furin Cleavage Site in SARS-CoV-2.
Mol Biol Evol
; 39(1)2022 01 07.
Article
in English
| MEDLINE | ID: covidwho-1522254
ABSTRACT
Compared with other SARS-related coronaviruses (SARSr-CoVs), SARS-CoV-2 possesses a unique furin cleavage site (FCS) in its spike. This has stimulated discussion pertaining to the origin of SARS-CoV-2 because the FCS has been observed to be under strong selective pressure in humans and confers the enhanced ability to infect some cell types and induce cell-cell fusion. Furthermore, scientists have demonstrated interest in studying novel cleavage sites by introducing them into SARSr-CoVs. We review what is known about the SARS-CoV-2 FCS in the context of its pathogenesis, origin, and how future wildlife coronavirus sampling may alter the interpretation of existing data.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Furin
/
Spike Glycoprotein, Coronavirus
Language:
English
Journal subject:
Molecular Biology
Year:
2022
Document Type:
Article
Affiliation country:
Molbev
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