The reactome pathway knowledgebase 2022.
Nucleic Acids Res
; 50(D1): D687-D692, 2022 01 07.
Article
in English
| MEDLINE | ID: covidwho-1522256
ABSTRACT
The Reactome Knowledgebase (https//reactome.org), an Elixir core resource, provides manually curated molecular details across a broad range of physiological and pathological biological processes in humans, including both hereditary and acquired disease processes. The processes are annotated as an ordered network of molecular transformations in a single consistent data model. Reactome thus functions both as a digital archive of manually curated human biological processes and as a tool for discovering functional relationships in data such as gene expression profiles or somatic mutation catalogs from tumor cells. Recent curation work has expanded our annotations of normal and disease-associated signaling processes and of the drugs that target them, in particular infections caused by the SARS-CoV-1 and SARS-CoV-2 coronaviruses and the host response to infection. New tools support better simultaneous analysis of high-throughput data from multiple sources and the placement of understudied ('dark') proteins from analyzed datasets in the context of Reactome's manually curated pathways.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Proteins
/
Knowledge Bases
Limits:
Humans
Language:
English
Journal:
Nucleic Acids Res
Year:
2022
Document Type:
Article
Affiliation country:
Nar
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