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Infection in asymptomatic carriers of SARS-CoV-2 can interfere with the achievement of robust immunity on a population scale
Journal of General Virology ; 102(11), 2021.
Article in English | CAB Abstracts | ID: covidwho-1722771
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread worldwide as a severe pandemic, and a significant portion of the infected population may remain asymptomatic. Given this, five surveys were carried out between May and September 2020 with a total of 3585 volunteers in the municipality of Foz do Igua..u, State of Paran.., a triple border region between Brazil/Argentina/Paraguay. Five months after the first infection, volunteers were re-analysed for the production of IgG anti-Spike and anti-RBD-Spike, in addition to analyses of cellular immunity. Seroconversion rates ranged from 4.4% to a peak of 37.21% followed by a reduction in seroconversion to 21.1% in September, indicating that 25% of the population lost their circulating anti-SARS-CoV-2 antibodies 3 months after infection. Analyses after 5 months of infection showed that only 17.2% of people still had anti-RBD-Spike antibodies, however, most volunteers had some degree of cellular immune response. The strategy of letting people become naturally infected with SARS-CoV-2 to achieve herd immunity is flawed, and the first contact with the virus may not generate enough immunogenic stimulus to prevent a possible second infection.
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Full text: Available Collection: Databases of international organizations Database: CAB Abstracts Language: English Journal: Journal of General Virology Year: 2021 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: CAB Abstracts Language: English Journal: Journal of General Virology Year: 2021 Document Type: Article