Infection in asymptomatic carriers of SARS-CoV-2 can interfere with the achievement of robust immunity on a population scale
Journal of General Virology
; 102(11), 2021.
Article
in English
| CAB Abstracts | ID: covidwho-1722771
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread worldwide as a severe pandemic, and a significant portion of the infected population may remain asymptomatic. Given this, five surveys were carried out between May and September 2020 with a total of 3585 volunteers in the municipality of Foz do Igua..u, State of Paran.., a triple border region between Brazil/Argentina/Paraguay. Five months after the first infection, volunteers were re-analysed for the production of IgG anti-Spike and anti-RBD-Spike, in addition to analyses of cellular immunity. Seroconversion rates ranged from 4.4% to a peak of 37.21% followed by a reduction in seroconversion to 21.1% in September, indicating that 25% of the population lost their circulating anti-SARS-CoV-2 antibodies 3 months after infection. Analyses after 5 months of infection showed that only 17.2% of people still had anti-RBD-Spike antibodies, however, most volunteers had some degree of cellular immune response. The strategy of letting people become naturally infected with SARS-CoV-2 to achieve herd immunity is flawed, and the first contact with the virus may not generate enough immunogenic stimulus to prevent a possible second infection.
Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210]; Human Immunology and Allergology [VV055]; Host Resistance and Immunity [HH600]; human diseases; viral diseases; antibodies; antigens; carrier state; cell mediated immunity; IgG; immune response; immunity; immunogenetics; infections; pandemics; seroconversion; coronavirus disease 2019; asymptomatic infections; Severe acute respiratory syndrome coronavirus 2; man; Severe acute respiratory syndrome coronavirus; Parana; Brazil; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Community of Portuguese Language Countries; high Human Development Index countries; Latin America; America; South America; upper-middle income countries; Coronavirus; SARS-CoV-2; viral infections; antigenicity; immunogens; cellular immunity; immunity reactions; immunological reactions
Full text:
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Collection:
Databases of international organizations
Database:
CAB Abstracts
Language:
English
Journal:
Journal of General Virology
Year:
2021
Document Type:
Article
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