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SARS Cov-2 vaccination induces de novo donor-specific HLA antibodies in a renal transplant patient on waiting list: A case report.
Abu-Khader, Ahmad; Wang, Wenjie; Berka, Meriam; Galaszkiewicz, Iwona; Khan, Faisal; Berka, Noureddine.
  • Abu-Khader A; Histocompatibility and Immunogenetics Laboratory, Alberta Precision Laboratories, Alberta, Canada.
  • Wang W; Department of Pathology and Laboratory Medicine, University of Calgary, Alberta, Canada.
  • Berka M; Department of Medicine, University of Calgary, Alberta, Canada.
  • Galaszkiewicz I; Department of Pathology and Laboratory Medicine, University of Calgary, Alberta, Canada.
  • Khan F; Histocompatibility and Immunogenetics Laboratory, Alberta Precision Laboratories, Alberta, Canada.
  • Berka N; Histocompatibility and Immunogenetics Laboratory, Alberta Precision Laboratories, Alberta, Canada.
HLA ; 99(1): 25-30, 2022 01.
Article in English | MEDLINE | ID: covidwho-1522855
ABSTRACT
The ability of COVID-19 vaccination to induce anti-HLA antibodies (Abs) formation in renal transplant candidates is not well studied. A 42-year-old man on a renal transplant waitlist, with no sensitization history, was tested for DSA before and after COVID-19 vaccination. Patient has consistently tested negative for COVID-19 virus. Eighteen days after receiving first dose of mRNA-based vaccine, flow cytometry crossmatch (FCXM) was strongly positive with de novo donor-specific Ab (dnDSA) against B57 and de novo non-DSA against B58. Before vaccination, preliminary FCXM was negative with no anti-HLA Abs. This event prompted the transplant team to cancel the surgery. COVID-19 vaccination could be associated with anti-HLA Abs formation in renal patients on waitlists that could affect future transplantability.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Kidney Transplantation / COVID-19 Vaccines / COVID-19 / Isoantibodies Type of study: Case report / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Adult / Humans / Male Language: English Journal: HLA Year: 2022 Document Type: Article Affiliation country: Tan.14492

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Kidney Transplantation / COVID-19 Vaccines / COVID-19 / Isoantibodies Type of study: Case report / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Adult / Humans / Male Language: English Journal: HLA Year: 2022 Document Type: Article Affiliation country: Tan.14492