Humoral immune response after COVID-19 in multiple sclerosis: A nation-wide Austrian study.
Mult Scler
; 27(14): 2209-2218, 2021 12.
Article
in English
| MEDLINE | ID: covidwho-1523230
ABSTRACT
BACKGROUND:
Knowledge on immunity after SARS-CoV-2 infection in patients with multiple sclerosis (pwMS) and the impact of disease-modifying treatment (DMT) is limited.OBJECTIVE:
To evaluate degree, duration and potential predictors of specific humoral immune response in pwMS with prior COVID-19.METHODS:
Anti-SARS-CoV-2 antibody testing was performed in pwMS with PCR-confirmed diagnosis of symptomatic COVID-19 from a nation-wide registry. Predictors of seropositivity were identified by multivariate regression models.RESULTS:
In 125 pwMS (mean age = 42.4 years (SD = 12.3 years), 70% female), anti-SARS-CoV-2 antibodies were detected in 76.0% after a median of 5.2 months from positive PCR. Seropositivity rate was significantly lower in patients on IS-DMT (61.4%, p = 0.001) than without DMT or immunomodulatory DMT (80.6%; 86.0%, respectively). In multivariate analysis, IS-DMT was associated with reduced probability of seropositivity (odds ratio (OR) 0.51; 95% confidence interval (95% CI) 0.17-0.82; p < 0.001). Predefined subgroup analyses showed marked reduction of seropositivity in pwMS on rituximab/ocrelizumab (OR 0.15; 95% CI 0.05-0.56; p < 0.001). Rate of seropositivity did not change significantly over 6 months.CONCLUSIONS:
Humoral immunity is stable after SARS-CoV-2 infection in MS, but is reduced by immunosuppressive DMT, particularly anti-CD20 monoclonal antibodies. This provides important evidence for advising pwMS as well as for planning and prioritizing vaccination.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Multiple Sclerosis
Type of study:
Experimental Studies
/
Prognostic study
Topics:
Vaccines
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
English
Journal:
Mult Scler
Journal subject:
Neurology
Year:
2021
Document Type:
Article
Affiliation country:
13524585211049391
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