TLRs in COVID-19: How they drive immunopathology and the rationale for modulation.
Innate Immun
; 27(7-8): 503-513, 2021 10.
Article
in English
| MEDLINE | ID: covidwho-1523254
ABSTRACT
COVID-19 is both a viral illness and a disease of immunopathology. Proximal events within the innate immune system drive the balance between deleterious inflammation and viral clearance. We hypothesize that a divergence between the generation of excessive inflammation through over activation of the TLR associated myeloid differentiation primary response (MyD88) pathway relative to the TIR-domain-containing adaptor-inducing IFN-ß (TRIF) pathway plays a key role in COVID-19 severity. Both viral elements and damage associated host molecules act as TLR ligands in this process. In this review, we detail the mechanism for this imbalance in COVID-19 based on available evidence, and we discuss how modulation of critical elements may be important in reducing severity of disease.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Toll-Like Receptors
/
COVID-19
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Innate Immun
Journal subject:
Allergy and Immunology
/
Bacteriology
Year:
2021
Document Type:
Article
Affiliation country:
17534259211051364
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