Role of miRNAs as biomarkers of COVID-19: a scoping review of the status and future directions for research in this field.
Biomark Med
; 15(18): 1785-1795, 2021 12.
Article
in English
| MEDLINE | ID: covidwho-1523644
ABSTRACT
Aim:
miRNAs are potential biomarkers of several diseases. This review aimed to identify the miRNAs that could serve as biomarkers of COVID-19. Materials &methods:
A literature search of nine databases was carried out for studies published before 13 June 2021 that described dysregulated miRNAs in cells or animals infected by SARS-CoV-2 or in patients with COVID-19. Two independent reviewers selected the studies and extracted data; disagreements were resolved by a third reviewer.Results:
Twenty studies were included in this scoping review; results suggested that miR-21-5p, miR-146a, miR-126-3p, miR-144 and miR-155 are the most important dysregulated miRNAs that could serve as biomarkers for diagnosing and indicating the severity of COVID-19. miRNAs appear to play key roles in viral replication, proliferation of infected cells, immune response, inflammation and cardiovascular dysfunction.Conclusion:
This review provides insights into the role of miRNAs as biomarkers in COVID-19 and the current status and future directions for research in this field.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Prognostic study
/
Reviews
Limits:
Humans
Language:
English
Journal:
Biomark Med
Journal subject:
Biochemistry
/
Medicine
Year:
2021
Document Type:
Article
Affiliation country:
Bmm-2021-0348
Similar
MEDLINE
...
LILACS
LIS