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A Comparative Study between Spanish and British SARS-CoV-2 Variants.
Jimenez Ruiz, Jose A; Lopez Ramirez, Cecilia; Lopez-Campos, Jose Luis.
  • Jimenez Ruiz JA; Research Group on Electronic Technology and Industrial Computing (TIC-150), Department of Artificial Intelligence, University of Seville, 41013 Sevilla, Spain.
  • Lopez Ramirez C; Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Universidad de Sevilla, 41013 Sevilla, Spain.
  • Lopez-Campos JL; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Curr Issues Mol Biol ; 43(3): 2036-2047, 2021 Nov 16.
Article in English | MEDLINE | ID: covidwho-1523887
ABSTRACT
The study of the interaction between the SARS-CoV-2 spike protein and the angiotensin-converting enzyme 2 (ACE2) receptor is key to understanding binding affinity and stability. In the present report, we sought to investigate the differences between two already sequenced genome variants (Spanish and British) of SARS-CoV-2.

Methods:

In silico model evaluating the homology, identity and similarity in the genome sequence and the structure and alignment of the predictive spike by computational docking methods.

Results:

The identity results between the Spanish and British variants of the Spike protein were 28.67%. This close correspondence in the results between the Spanish and British SARS-CoV-2 variants shows that they are very similar (99.99%). The alignment obtained results in four deletions. There were 23 nucleotide substitutions also predicted which could affect the functionality of the proteins produced from this sequence. The interaction between the binding receptor domain from the spike protein and the ACE2 receptor produces some of the mutations found and, therefore, the energy of this ligand varies. However, the estimated antigenicity of the British variant is higher than its Spanish counterpart.

Conclusions:

Our results indicate that minimal mutations could interfere in the infectivity of the virus due to changes in the fitness between host cell recognition and interaction proteins. In particular, the N501Y substitution, situated in the RBD of the spike of the British variant, might be the reason for its extraordinary infective potential.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Internalization / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Topics: Variants Limits: Humans Country/Region as subject: Europa Language: English Journal: Curr Issues Mol Biol Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: Cimb43030140

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Internalization / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Topics: Variants Limits: Humans Country/Region as subject: Europa Language: English Journal: Curr Issues Mol Biol Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: Cimb43030140