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Antibody Titer Kinetics and SARS-CoV-2 Infections Six Months after Administration with the BNT162b2 Vaccine.
Ferrari, Davide; Clementi, Nicola; Criscuolo, Elena; Ambrosi, Alessandro; Corea, Francesca; Di Resta, Chiara; Tomaiuolo, Rossella; Mancini, Nicasio; Locatelli, Massimo; Plebani, Mario; Banfi, Giuseppe.
  • Ferrari D; Scienze Chimiche della Vita e della Sostenibilità Ambientale (CVSA) Department, University of Parma, 43121 Parma, Italy.
  • Clementi N; Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20158 Milan, Italy.
  • Criscuolo E; IRCCS Ospedale San Raffaele, Laboratory Medicine Service, 20158 Milan, Italy.
  • Ambrosi A; Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20158 Milan, Italy.
  • Corea F; Surgery and Medicne Depertment, University Vita-Salute San Raffaele, 20158 Milan, Italy.
  • Di Resta C; IRCCS Ospedale San Raffaele, Laboratory Medicine Service, 20158 Milan, Italy.
  • Tomaiuolo R; IRCCS Ospedale San Raffaele, Laboratory Medicine Service, 20158 Milan, Italy.
  • Mancini N; Surgery and Medicne Depertment, University Vita-Salute San Raffaele, 20158 Milan, Italy.
  • Locatelli M; Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20158 Milan, Italy.
  • Plebani M; IRCCS Ospedale San Raffaele, Laboratory Medicine Service, 20158 Milan, Italy.
  • Banfi G; IRCCS Ospedale San Raffaele, Laboratory Medicine Service, 20158 Milan, Italy.
Vaccines (Basel) ; 9(11)2021 Nov 19.
Article in English | MEDLINE | ID: covidwho-1524229
ABSTRACT

BACKGROUND:

Studies reporting the long-term humoral response after receiving the BNT162b2 COVID-19 vaccine are important to drive future vaccination strategies. Yet, available literature is scarce. Covidiagnostix is a multicenter study designed to assess the antibody response in >1000 healthcare professionals (HCPs) who received the BNT162b2 vaccine.

METHODS:

Serum was tested at time-0 (T0), before the first dose, T1, T2, and T3, respectively, 21, 42, and 180 days after T0. Antibodies against the SARS-CoV-2 nucleocapsid-protein were measured to assess SARS-CoV-2 infections, whereas antibodies against the receptor-binding domain of the spike protein were measured to assess the vaccine response. Neutralization activity against the D614G, B.1.1.7, and B.1.351 variants were also analyzed.

RESULTS:

Six months post-vaccination HCPs showed an antibody titer decrease of approximately 70%, yet, the titer was still one order of magnitude higher than that of seropositive individuals before vaccination. We identified 12 post-vaccination infected HCPs. None showed severe symptoms. Interestingly, most of them showed titers at T2 above the neutralization thresholds obtained from the neutralization activity experiments.

CONCLUSION:

Vaccination induces a humoral response which is well detectable even six months post-vaccination. Vaccination prevents severe COVID-19 cases, yet post-vaccination infection is possible even in the presence of a high anti-S serum antibody titer.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Long Covid / Vaccines / Variants Language: English Year: 2021 Document Type: Article Affiliation country: Vaccines9111357

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Long Covid / Vaccines / Variants Language: English Year: 2021 Document Type: Article Affiliation country: Vaccines9111357