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Role of membrane proteins in bacterial resistance to antimicrobial peptides.
Vimberg, Vladimir; Buriánková, Karolína; Mazumdar, Aninda; Branny, Pavel; Novotná, Gabriela B.
  • Vimberg V; Laboratory for Biology of Secondary Metabolism, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.
  • Buriánková K; Laboratory of Cell Signaling, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.
  • Mazumdar A; Laboratory for Biology of Secondary Metabolism, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.
  • Branny P; Laboratory of Cell Signaling, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.
  • Novotná GB; Laboratory for Biology of Secondary Metabolism, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.
Med Res Rev ; 42(3): 1023-1036, 2022 05.
Article in English | MEDLINE | ID: covidwho-1525477
ABSTRACT
Several natural antimicrobial peptides (AMPs), including the novel semisynthetic lipoglycopeptide antibiotics telavancin, dalbavancin, and oritavancin, have been approved for clinical use to address the growing problem of multiple antibiotic-resistant Gram-positive bacterial infections. Nevertheless, the efficacy of these antibiotics has already been compromised. The SARS-CoV-2 pandemic led to the increased clinical use of all antibiotics, further promoting the development of bacterial resistance. Therefore, it is critical to gain a deeper understanding of the role of resistance mechanisms to minimize the consequential risks of long-term antibiotic use and misuse. Here, we summarize for the first time the current knowledge of resistance mechanisms that have been shown to cause resistance to clinically used AMPs, with particular focus on membrane proteins that have been reported to interfere with the activity of AMPs by affecting the binding of AMPs to bacteria.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gram-Positive Bacterial Infections / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Med Res Rev Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gram-Positive Bacterial Infections / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Med Res Rev Year: 2022 Document Type: Article