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Dynamics of Antibodies to Various Antigens of the SARS-CoV-2 Coronavirus in Patients with Confirmed COVID-19 Infection.
Aleshkin, A V; Novikova, L I; Bochkareva, S S; Kombarova, S Yu; Lebedin, Yu S; Vorob'ev, A M; Mekhtiev, E R; Zul'karneev, E R; Laishevtsev, A I; Karaulov, A V.
  • Aleshkin AV; G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia.
  • Novikova LI; G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia.
  • Bochkareva SS; G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia.
  • Kombarova SY; G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia.
  • Lebedin YS; XEMA Co., Ltd., Moscow, Russia.
  • Vorob'ev AM; G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia. vorobjew.alex2010@yandex.ru.
  • Mekhtiev ER; G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia.
  • Zul'karneev ER; Сenter of Food Biotechnological Processing, Institute of Applied Microecology LLC, Moscow, Russia.
  • Laishevtsev AI; Сenter of Food Biotechnological Processing, Institute of Applied Microecology LLC, Moscow, Russia.
  • Karaulov AV; G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia.
Bull Exp Biol Med ; 171(2): 230-233, 2021 May.
Article in English | MEDLINE | ID: covidwho-1525548
ABSTRACT
The presence of IgG and IgM antibodies in the venous blood of 76 patients with confirmed COVID-19 infection was determined by ELISA using Russian test systems. Different levels of IgM antibodies to N-protein and receptor binding domain of the Spike protein (RBD) were revealed. The dynamics of IgG antibodies to the whole virion antigen and recombinant antigens showed high values on weeks 4-5 of the disease. The level of IgG antibodies to Nprotein remained low throughout the observation period. The characteristic dynamics of IgG measured using test systems with sorbed whole virion or recombinant spike proteins reflects the duration of the disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Immunoglobulin M / Spike Glycoprotein, Coronavirus / Coronavirus Nucleocapsid Proteins / COVID-19 / Antibodies, Viral / Antigens, Viral Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: Bull Exp Biol Med Year: 2021 Document Type: Article Affiliation country: S10517-021-05200-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Immunoglobulin M / Spike Glycoprotein, Coronavirus / Coronavirus Nucleocapsid Proteins / COVID-19 / Antibodies, Viral / Antigens, Viral Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: Bull Exp Biol Med Year: 2021 Document Type: Article Affiliation country: S10517-021-05200-9