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Comparison between myocardial function assessed by echocardiography during hospitalization for COVID-19 and at 4 months follow-up.
van den Heuvel, F M A; Vos, J L; van Bakel, B; Duijnhouwer, A L; van Dijk, A P J; Dimitriu-Leen, A C; Koopmans, P C; de Mast, Q; van de Veerdonk, F L; Bosch, F H; van den Borst, B; Eijsvogels, T M H; van Kimmenade, R R J; Nijveldt, R.
  • van den Heuvel FMA; Department of Cardiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
  • Vos JL; Department of Cardiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
  • van Bakel B; Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Duijnhouwer AL; Department of Cardiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
  • van Dijk APJ; Department of Cardiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
  • Dimitriu-Leen AC; Department of Cardiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
  • Koopmans PC; Section Biostatistics, Department of Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.
  • de Mast Q; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
  • van de Veerdonk FL; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Bosch FH; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
  • van den Borst B; Department of Pulmonology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Eijsvogels TMH; Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
  • van Kimmenade RRJ; Department of Cardiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
  • Nijveldt R; Department of Cardiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands. robin@nijveldt.net.
Int J Cardiovasc Imaging ; 37(12): 3459-3467, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1525550
ABSTRACT
In patients hospitalized for corona virus infectious disease 19 (COVID-19) it is currently unknown whether myocardial function changes after recovery and whether this is related to elevated cardiac biomarkers. In this single center, prospective cohort study we consecutively enrolled hospitalized COVID-19 patients between 1 April and 12 May 2020. All patients underwent transthoracic echocardiography (TTE) evaluation during hospitalization and at a median of 131 days (IQR; 116-136) follow-up. Of the 51 patients included at baseline, 40 (age 62 years (IQR; 54-68), 78% male) were available for follow-up TTE. At baseline, 68% of the patients had a normal TTE, regarding left ventricular (LV) and right ventricular (RV) volumes and function, compared to 83% at follow-up (p = 0.07). Median LV ejection fraction (60% vs. 58%, p = 0.54) and tricuspid annular plane systolic excursion (23 vs 22 mm, p = 0.18) were comparable between hospitalization and follow-up, but a significantly lower RV diameter (39 vs. 34 mm, p = 0.002) and trend towards better global longitudinal strain (GLS) (- 18.5% vs - 19.1%, p = 0.07) was found at follow-up. Subgroup analysis showed no relation between patients with and without elevated TroponinT and/or NT-proBNP during hospitalization and myocardial function at follow-up. Although there were no significant differences in individual myocardial function parameters at 4 months follow-up compared to hospitalisation for COVID-19, there was an overall trend towards normalization in myocardial function, predominantly due to a higher rate of normal GLS at follow-up.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Communicable Diseases / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Male / Middle aged Language: English Journal: Int J Cardiovasc Imaging Journal subject: Diagnostic Imaging Year: 2021 Document Type: Article Affiliation country: S10554-021-02346-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Communicable Diseases / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Male / Middle aged Language: English Journal: Int J Cardiovasc Imaging Journal subject: Diagnostic Imaging Year: 2021 Document Type: Article Affiliation country: S10554-021-02346-5