Arglabin could target inflammasome-induced ARDS and cytokine storm associated with COVID-19.
Mol Biol Rep
; 48(12): 8221-8225, 2021 Dec.
Article
in English
| MEDLINE | ID: covidwho-1525563
ABSTRACT
Arglabin (l(R),10(S)-epoxy-5(S),5(S),7(S)-guaia-3(4),ll(13)-dien-6,12-olide), is a natural sesquiterpene γ-lactone which was first isolated from Artemisia glabella. The compound has been shown to possess anti-inflammatory activity through inhibition of the NLR Family pyrin domain-containing 3 (NLRP3) inflammasome and production of proinflammatory cytokines including interleukin (IL)-1ß and IL-18. A more hydrophilic derivative of the compound also exhibited antitumor activity in the breast, colon, ovarian, and lung cancer. Some other synthetic derivatives of the compound have also been synthesized with antitumor, cytotoxic, antibacterial, and antifungal activities. Since both NLRP3 inflammasome and cytokine storm are associated with the pathogenesis of COVID-19 and its lethality, compounds like arglabin might have therapeutic potential to attenuate the inflammasome-induced acute respiratory distress syndrome and/or the cytokine storm associated with COVID-19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Sesquiterpenes, Guaiane
/
SARS-CoV-2
/
COVID-19 Drug Treatment
Topics:
Traditional medicine
Limits:
Humans
Language:
English
Journal:
Mol Biol Rep
Year:
2021
Document Type:
Article
Affiliation country:
S11033-021-06827-7
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