Potential Emergence of Plasmodium Resistance to Artemisinin Induced by the Use of Artemisia annua for Malaria and COVID-19 Prevention in Sub-African Region.
Acta Parasitol
; 67(1): 55-60, 2022 Mar.
Article
in English
| MEDLINE | ID: covidwho-1525614
ABSTRACT
Plasmodium resistance to antimalarial drugs is an obstacle to the elimination of malaria in endemic areas. This situation is particularly dramatic for Africa, which accounts for nearly 92% of malaria cases worldwide. Drug pressure has been identified as a key factor in the emergence of antimalarial drug resistance. Indeed, this pressure is favoured by several factors, including the use of counterfeit forms of antimalarials, inadequate prescription controls, poor adherence to treatment regimens, dosing errors, and the increasing use of other forms of unapproved antimalarials. This resistance has led to the replacement of chloroquine (CQ) by artemisinin-based combination therapies (ACTs) which are likely to become ineffective in the coming years due to the uncontrolled use of Artemisia annua in the sub-Saharan African region for malaria prevention and COVID-19. The use of Artemisia annua for the prevention of malaria and COVID-19 could be an important factor in the emergence of resistance to Artemisinin-based combination therapies.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Plasmodium
/
Malaria, Falciparum
/
Artemisia annua
/
Artemisinins
/
COVID-19
/
Malaria
/
Antimalarials
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Acta Parasitol
Year:
2022
Document Type:
Article
Affiliation country:
S11686-021-00489-y
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