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Does a lack of vaccine side effects correlate with reduced BNT162b2 mRNA vaccine response among healthcare workers and nursing home residents?
Oyebanji, Oladayo A; Wilson, Brigid; Keresztesy, Debbie; Carias, Lenore; Wilk, Dennis; Payne, Michael; Aung, Htin; Denis, Kerri St; Lam, Evan C; Rowley, Christopher F; Berry, Sarah D; Cameron, Cheryl M; Cameron, Mark J; Schmader, Kenneth E; Balazs, Alejandro B; King, Christopher L; Canaday, David H; Gravenstein, Stefan.
  • Oyebanji OA; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Wilson B; Geriatric Research, Education and Clinical Center, VA Northeast Ohio Healthcare System, Cleveland, OH, USA.
  • Keresztesy D; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Carias L; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Wilk D; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Payne M; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Aung H; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Denis KS; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Lam EC; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Rowley CF; Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Berry SD; Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
  • Cameron CM; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Cameron MJ; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Schmader KE; Geriatric Research, Education and Clinical Center, Durham VA Health Care System and Duke University Medical Center, Durham, NC, USA.
  • Balazs AB; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • King CL; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Canaday DH; Case Western Reserve University School of Medicine, Cleveland, OH, USA. David.canaday@case.edu.
  • Gravenstein S; Geriatric Research, Education and Clinical Center, VA Northeast Ohio Healthcare System, Cleveland, OH, USA. David.canaday@case.edu.
Aging Clin Exp Res ; 33(11): 3151-3160, 2021 Nov.
Article in English | MEDLINE | ID: covidwho-1525638
ABSTRACT

BACKGROUND:

The BNT162b2 SARS-CoV-2 mRNA vaccination has mitigated the burden of COVID-19 among residents of long-term care facilities considerably, despite being excluded from the vaccine trials. Data on reactogenicity (vaccine side effects) in this population are limited.

AIMS:

To assess reactogenicity among nursing home (NH) residents. To provide a plausible proxy for predicting vaccine response among this population.

METHODS:

We enrolled and sampled NH residents and community-dwelling healthcare workers who received the BNT162b2 mRNA vaccine, to assess local or systemic reactogenicity and antibody levels (immunogenicity).

RESULTS:

NH residents reported reactions at a much lower frequency and lesser severity than the community-dwelling healthcare workers. These reactions were mild and transient with all subjects experiencing more local than systemic reactions. Based on our reactogenicity and immunogenicity data, we developed a linear regression model predicting log-transformed anti-spike, anti-receptor-binding domain (RBD), and neutralizing titers, with a dichotomous variable indicating the presence or absence of reported reactions which revealed a statistically significant effect, with estimated shifts in log-transformed titers ranging from 0.32 to 0.37 (all p < 0.01) indicating greater immunogenicity in subjects with one or more reported reactions of varying severity.

DISCUSSION:

With a significantly lower incidence of post-vaccination reactions among NH residents as reported in this study, the BNT162b2 mRNA vaccine appears to be well-tolerated among this vulnerable population. If validated in larger populations, absence of reactogenicity could help guide clinicians in prioritizing vaccine boosters.

CONCLUSIONS:

Reactogenicity is significantly mild among nursing home residents and overall, subjects who reported post-vaccination reactions developed higher antibody titers.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Vaccines / COVID-19 Subject: Vaccines / COVID-19 Type of study: Prognostic study / Qualitative research Language: English Journal: Aging Clin Exp Res Clinical aspect: Prediction / Prognosis Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Vaccines / COVID-19 Subject: Vaccines / COVID-19 Type of study: Prognostic study / Qualitative research Language: English Journal: Aging Clin Exp Res Clinical aspect: Prediction / Prognosis Year: 2021
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