COVID-19 in children and young adults with moderate/severe inborn errors of immunity in a high burden area in pre-vaccine era.
Clin Immunol
; 230: 108821, 2021 09.
Article
in English
| MEDLINE | ID: covidwho-1525729
ABSTRACT
BACKGROUND:
Information regarding inborn error of immunity (IEI) as a risk factor for severe COVID-19 is scarce. We aimed to determine if paediatric patients with moderate/severe IEI got COVID-19 at the same level as the general population, and to describe COVID-19 expression. MATERIAL ANDMETHODS:
We included patients with moderate/severe IEI aged 0-21 years old cross-sectional study (June2020) to determine the prevalence of COVID-19; prospective study (January2020-January2021) including IEI patients with COVID-19. Assays used nasopharyngeal swab SARS-CoV-2 PCR and SARS-CoV-2-specific immunoglobulins.RESULTS:
Seven from sixty-five patients tested positive (prevalence 10.7% (7%-13%)) after the first SARS-COV-2 wave and 13/15 patients diagnosed with COVID-19 had an asymptomatic/mild course.CONCLUSIONS:
In our area, prevalence of COVID-19 in moderate/severe IEI paediatric patients after the first wave was slightly higher than in the general population. The majority of patients presented a benign course, suggesting a possible protective factor related with age despite IEI.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Primary Immunodeficiency Diseases
/
SARS-CoV-2
/
COVID-19
Type of study:
Cohort study
/
Etiology study
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
/
Vaccines
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Young adult
Language:
English
Journal:
Clin Immunol
Journal subject:
Allergy and Immunology
Year:
2021
Document Type:
Article
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